Kuloglu Ersin, Sengul Ilker, Sengul Demet, Muhtaroglu Ali, Aslan Sefer, Issever Kubilay, Dulger Ahmet Cumhur
Department of Internal Medicine, Faculty of Medicine, Giresun University, Gazipasa Compound, Gazi Avenue, 28100, Giresun, Turkey.
Division of Endocrine Surgery, Faculty of Medicine, Giresun University, Giresun, Turkey.
Eur Geriatr Med. 2025 Apr 10. doi: 10.1007/s41999-025-01197-w.
Dyspeptic complaints are common across all age groups, but limited research explores their characteristics and underlying pathologies in nonagenarians. This pioneering study aims to investigate the clinical, laboratory, and histopathological features in women nonagenarians vs. middle-aged.
A cross-sectional study included 93 female nonagenarians and 90 under 65 years (control), all presenting with dyspeptic complaints to general surgery, internal medicine, and gastroenterology outpatient clinics. Both groups underwent comprehensive evaluations, including laboratory parameters, upper gastric endoscopic examinations, and histopathological assessments of gastric biopsies. Statistical analysis compared the two groups' demographic, laboratory, and histopathological findings.
Of the patients included in the study, 49.8% were under 65 years, and 50.2% were nonagenarians. The mean age of the control group was 54.8 years, while nonagenarians had a mean age of 92.7 years. Significant differences were observed in several laboratory biomarkers such as leukocytes, neutrophils, glucose, creatinine, sodium, potassium, albumin, alanine transaminase, C-reactive protein, etc. between the groups (p < 0.05). Nonagenarians were less infected with Helicobacter pylori, whereas they had a higher frequency of intestinal metaplasia.
Nonagenarians group has a higher rate of intestinal metaplasia and displasia, while a lower rate of Helicobacter pylori infection in their gastric mucosal specimens. More extensive randomized controlled trials should illuminate the possible pathophysiological mechanisms for this association.
消化不良症状在所有年龄组中都很常见，但针对九旬老人消化不良特征及其潜在病理机制的研究有限。这项开创性研究旨在调查九旬女性与中年女性的临床、实验室及组织病理学特征。
一项横断面研究纳入了93名九旬女性和90名65岁以下女性（对照组），所有患者均因消化不良症状前往普通外科、内科和胃肠病门诊就诊。两组均接受了全面评估，包括实验室指标、上消化道内镜检查以及胃活检的组织病理学评估。统计分析比较了两组的人口统计学、实验室和组织病理学结果。
在纳入研究的患者中，49.8%为65岁以下，50.2%为九旬老人。对照组的平均年龄为54.8岁，而九旬老人的平均年龄为92.7岁。两组之间在白细胞、中性粒细胞、葡萄糖、肌酐、钠、钾、白蛋白、丙氨酸转氨酶、C反应蛋白等多项实验室生物标志物方面存在显著差异（p<0.05）。九旬老人幽门螺杆菌感染率较低，而肠化生发生率较高。
九旬老人组胃黏膜标本中肠化生和发育异常发生率较高，幽门螺杆菌感染率较低。更多广泛的随机对照试验应阐明这种关联可能的病理生理机制。
