Sheek-Hussein Mohamud, Zewude Aboma, Abdullahi Aminu S, Abdelgaleel Nabeeha Hassan, Ishag Hassan Zackaria Ali, Yusof Mohd Farouk, ALBreiki Mohammed Saleh, Shah Asma Mohamed Abdi, AlNeyadi Jamila, Osman Babiker, Hassen Amir Abdullah, Al Nuaimat Mervat Mari, Kayaf Kaltham, Hamad Mohamed Elfatih, Alsuwaidi Ahmed R, Ádám Balázs, Barigye Robert, Ameni Gobena
Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain city, Abu Dhabi, United Arab Emirates.
School of Public Health, Loma Linda University, Loma Linda, CA, USA.
Sci Rep. 2025 Apr 10;15(1):12308. doi: 10.1038/s41598-025-97167-0.
Coxiellosis is a zoonotic bacterial disease caused by Coxiella burnetii (C. burnetii) infection that occurs as subclinical and clinical infections in animals and humans worldwide except in the Antarctica and New Zealand. The objectives of this study were to estimate the seroprevalences of C. burnetti infections in slaughtered camels and abattoir workers as well as to detect C. burnetii DNA in the clotted blood in the same study subjects at Al Bawadi abattoir of Al Ain city, in the United Arab Emirates, UAE. A cross-sectional study design was used to test 393 slaughtered camels and 86 abattoir workers for C. burnetii antibodies between March 2022 and July 2023 using enzyme-linked immunosorbent assay (ELISA) kits supplied by ID Vet multispecies and Abbexa, respectively. Besides, real-time polymerase chain reaction (qPCR) was used for the detection of C. burnetti DNA in clotted blood of 366 camels and 86 abattoir workers. The seroprevalences of C. burnetii infection were 52.9% (95% confidence interval, CI: 46.0, 60.6%) and 24.4% (95% CI: 15.1, 37.3%) in camels and abattoir workers. But, C. burnetii DNA was not detected in clotted blood samples of camels and abattoir workers. Sex, age and body condition of the camels were not associated with the seroprevalence of C. burnetii while abattoir workers of African origin were more likely to be seropositive (odds ratio, OR = 3.70; 95% CI: 1.05, 13.60) than abattoir workers of south Asian origin. The seroprevalences of C. burnetii infections were high in both slaughtered camels and abattoir workers although its DNA was not detected in the clotted blood of either of the study subjects.
寇热是一种人畜共患细菌性疾病，由伯纳特立克次体（C. burnetii）感染引起，除南极洲和新西兰外，在全球范围内的动物和人类中均有亚临床和临床感染病例。本研究的目的是估计阿联酋艾因市巴瓦迪屠宰场屠宰骆驼和屠宰场工人中伯纳特立克次体感染的血清流行率，并检测同一研究对象凝血样本中的伯纳特立克次体DNA。采用横断面研究设计，分别使用ID Vet多物种试剂盒和Abbexa试剂盒，在2022年3月至2023年7月期间对393头屠宰骆驼和86名屠宰场工人进行伯纳特立克次体抗体检测。此外，采用实时聚合酶链反应（qPCR）检测366头骆驼和86名屠宰场工人凝血样本中的伯纳特立克次体DNA。骆驼和屠宰场工人中伯纳特立克次体感染的血清流行率分别为52.9%（95%置信区间，CI：46.0，60.6%）和24.4%（95%CI：15.1，37.3%）。但是，在骆驼和屠宰场工人的凝血样本中未检测到伯纳特立克次体DNA。骆驼的性别、年龄和身体状况与伯纳特立克次体的血清流行率无关，而非洲裔屠宰场工人比南亚裔屠宰场工人血清阳性的可能性更高（优势比，OR = 3.70；95%CI：1.05，13.60）。尽管在任何一个研究对象的凝血样本中均未检测到伯纳特立克次体DNA，但屠宰骆驼和屠宰场工人中伯纳特立克次体感染的血清流行率均较高。
