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纳米技术介导的蛋白质无创透皮和局部给药的最新进展

Recent Advances in Nanotechnology-Mediated Noninvasive Transdermal and Topical Delivery of Proteins.

作者信息

Ko Junghyeon, Kim Jeong-Uk, Choi Subin, Kim Ye-Sol, Park Su-Bin, Kim Joo-Young, Kim Hyeon-Jin, Lee Young-Sun, An Young-Hyeon, Hwang Nathaniel S

机构信息

School of Chemical and Biological Engineering Institute of Chemical Processes Seoul National University Seoul 08826 Republic of Korea.

Interdisciplinary Program in Bioengineering Seoul National University Seoul 08826 Republic of Korea.

出版信息

Small Sci. 2024 Jul 16;4(10):2400175. doi: 10.1002/smsc.202400175. eCollection 2024 Oct.

DOI:10.1002/smsc.202400175
PMID:40212262
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11935111/
Abstract

Protein therapeutics are emerging as essential technologies due to their functional and chemical properties. However, their application is currently limited to delivery by oral and injection methods-the former being inefficient and the latter invasive and potentially tissue damaging. Researchers are, therefore, exploring noninvasive delivery systems for proteins through the skin, including transdermal and topical delivery. The large molecular size of proteins presents a key challenge for skin penetration, hindering their ability to penetrate the dense skin lamellar structure. This review focuses on using nanoparticles as carriers to increase protein stability and enhance skin penetration. The use of noninvasive or minimally invasive enhancers for controlling and improving penetration depth is also examined. Furthermore, the physical properties of nanoparticles that affect delivery are evaluated, aiming to propose ways to advance transdermal and topical delivery methods in the future.

摘要

由于其功能和化学特性，蛋白质疗法正成为关键技术。然而，它们目前的应用仅限于口服和注射方式给药——前者效率低下，后者具有侵入性且可能对组织造成损伤。因此，研究人员正在探索通过皮肤进行蛋白质的非侵入性给药系统，包括透皮给药和局部给药。蛋白质的大分子尺寸对皮肤渗透构成了关键挑战，阻碍了它们穿透致密的皮肤层状结构的能力。本综述着重于使用纳米颗粒作为载体来提高蛋白质稳定性并增强皮肤渗透性。还研究了使用非侵入性或微创增强剂来控制和提高渗透深度。此外，评估了影响给药的纳米颗粒的物理性质，旨在提出未来推进透皮和局部给药方法的途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dda/11935111/17a322c21ef8/SMSC-4-2400175-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dda/11935111/3c6ea0775351/SMSC-4-2400175-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dda/11935111/700ead4a4e6b/SMSC-4-2400175-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dda/11935111/3c2f74bdec14/SMSC-4-2400175-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dda/11935111/d173f374e4c5/SMSC-4-2400175-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dda/11935111/27b90c2e6014/SMSC-4-2400175-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dda/11935111/9299c23aecd2/SMSC-4-2400175-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dda/11935111/d39be954aa10/SMSC-4-2400175-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dda/11935111/17a322c21ef8/SMSC-4-2400175-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dda/11935111/3c6ea0775351/SMSC-4-2400175-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dda/11935111/700ead4a4e6b/SMSC-4-2400175-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dda/11935111/3c2f74bdec14/SMSC-4-2400175-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dda/11935111/d173f374e4c5/SMSC-4-2400175-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dda/11935111/27b90c2e6014/SMSC-4-2400175-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dda/11935111/9299c23aecd2/SMSC-4-2400175-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dda/11935111/d39be954aa10/SMSC-4-2400175-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dda/11935111/17a322c21ef8/SMSC-4-2400175-g006.jpg

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ACS Nano. 2024 Jun 11;18(23):14938-14953. doi: 10.1021/acsnano.4c00206. Epub 2024 May 10.
2
Chitosan nanoparticle toxicity: A comprehensive literature review of and assessments for medical applications.壳聚糖纳米颗粒毒性：医学应用的体外和体内评估综合文献综述
Toxicol Rep. 2023 Jun 29;11:83-106. doi: 10.1016/j.toxrep.2023.06.012. eCollection 2023 Dec.
3
Single-Walled Carbon Nanotube-Guided Topical Skin Delivery of Tyrosinase to Prevent Photoinduced Damage.
单壁碳纳米管引导的酪氨酸酶经皮给药预防光诱导损伤。
ACS Nano. 2023 Oct 24;17(20):20473-20491. doi: 10.1021/acsnano.3c06846. Epub 2023 Oct 4.
4
Subcutaneous angiogenesis induced by transdermal delivery of gel-in-oil nanogel dispersion.经皮传递油包水型纳米胶束分散体诱导皮下血管生成。
Biomater Adv. 2023 Nov;154:213628. doi: 10.1016/j.bioadv.2023.213628. Epub 2023 Sep 19.
5
Double Emulsion-Mediated Delivery of Polyphenol Mixture Alleviates Atopic Dermatitis.双乳液介导递送多酚混合物缓解特应性皮炎。
Adv Healthc Mater. 2023 Dec;12(30):e2300998. doi: 10.1002/adhm.202300998. Epub 2023 Sep 17.
6
Transdermal Sustained Release Properties and Anti-Photoaging Efficacy of Liposome-Thermosensitive Hydrogel System.脂质体-温敏水凝胶系统的经皮持续释放性能和抗光老化功效。
Adv Healthc Mater. 2024 Jan;13(2):e2301933. doi: 10.1002/adhm.202301933. Epub 2023 Aug 31.
7
Liposome-assisted penetration and antiaging effects of collagen in a 3D skin model.脂质体辅助胶原蛋白在 3D 皮肤模型中的渗透和抗衰老作用。
J Cosmet Dermatol. 2024 Jan;23(1):236-243. doi: 10.1111/jocd.15912. Epub 2023 Jul 6.
8
Recent Advancement of Medical Patch for Transdermal Drug Delivery.医学贴片经皮给药的最新进展。
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ACS Omega. 2023 Mar 3;8(10):9239-9249. doi: 10.1021/acsomega.2c07343. eCollection 2023 Mar 14.
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Adv Drug Deliv Rev. 2023 May;196:114770. doi: 10.1016/j.addr.2023.114770. Epub 2023 Mar 7.