Functionalized Bacterial Cellulose Bottlebrush-Based Asymmetric Dressing for Effective Management of Wounds with Infection and Exudate.

Simultaneous infection and exudate management remain a great challenge in wound treatment. As one of the most promising approaches, current asymmetric dressings are basically prepared through electrospinning with different kinds of materials, and the interfacial interaction remains unexplored. Herein, the first single-substrate-based asymmetric dressing with a well-entangled interface, large absorptive capacity, effective fluid reflux prevention, excellent antibacterial, and antipenetration properties is developed. The asymmetric dressing is composed of layered hydrophilic and hydrophobic bottlebrushes (sodium polyacrylate and polystyrene-functionalized bacterial cellulose), which are assembled using stepwise vacuum filtration, accompanied by loading triclosan into the solution of hydrophilic bottlebrushes. The biocompatibility and feasibility of the asymmetric dressing pave the way in real wound management.