Yang Zifeng, Wang Feng, Shi Chenguang, Huang Junlong, Xu Ruijun, Quan Luna, Li Yang, Sun Qi, Wang Hui, Huang Rongkang, Zheng Bingna, Li Yong
Department of Gastrointestinal Surgery Department of General Surgery Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou 510080 China.
Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangzhou 510080 China.
Small Sci. 2023 Nov 20;3(12):2300138. doi: 10.1002/smsc.202300138. eCollection 2023 Dec.
Simultaneous infection and exudate management remain a great challenge in wound treatment. As one of the most promising approaches, current asymmetric dressings are basically prepared through electrospinning with different kinds of materials, and the interfacial interaction remains unexplored. Herein, the first single-substrate-based asymmetric dressing with a well-entangled interface, large absorptive capacity, effective fluid reflux prevention, excellent antibacterial, and antipenetration properties is developed. The asymmetric dressing is composed of layered hydrophilic and hydrophobic bottlebrushes (sodium polyacrylate and polystyrene-functionalized bacterial cellulose), which are assembled using stepwise vacuum filtration, accompanied by loading triclosan into the solution of hydrophilic bottlebrushes. The biocompatibility and feasibility of the asymmetric dressing pave the way in real wound management.
在伤口治疗中，同时进行感染控制和渗出液管理仍然是一项巨大的挑战。作为最具前景的方法之一，目前的不对称敷料基本上是通过使用不同材料进行静电纺丝制备的，但其界面相互作用仍未得到探索。在此，开发出了第一种基于单一基底的不对称敷料，其具有缠结良好的界面、大吸收容量、有效的防液体回流、优异的抗菌和抗渗透性能。该不对称敷料由分层的亲水性和疏水性瓶刷（聚丙烯酸钠和聚苯乙烯功能化细菌纤维素）组成，通过逐步真空过滤组装而成，同时将三氯生负载到亲水性瓶刷溶液中。这种不对称敷料的生物相容性和可行性为实际伤口管理铺平了道路。
