Dörries R, Liebert U G, ter Meulen V
Institut für Virologie und Immunbiologie der Universität, Würzburg, F.R.G.
J Neuroimmunol. 1988 Oct;19(4):339-52. doi: 10.1016/0165-5728(88)90014-8.
The intrathecal humoral immune response was analysed in patients with subacute sclerosing panencephalitis (SSPE) and Lewis rats with subacute measles virus (MV)-induced encephalomyelitis (SAME). SSPE patients as well as SAME rats revealed oligoclonal, intrathecal antibody synthesis with MV specificity. SAME rats synthesized MV-specific antibodies intracerebrally to a higher extent than SSPE patients. Although a restricted isoelectric pattern of MV-specific antibodies was detected in the cerebrospinal fluid (CSF) of SSPE patients as well as of SAME rats, the heterogeneity within clusters of immunoglobulin bands was higher in the rat specimens. Increase in the blood-brain barrier permeability for albumin was exclusively detected in SAME rats but not in SSPE patients. These data suggest that the rat model offers excellent opportunities to study the initial humoral events in MV-induced encephalitides.
对亚急性硬化性全脑炎（SSPE）患者和患有亚急性麻疹病毒（MV）诱导性脑脊髓炎（SAME）的Lewis大鼠的鞘内体液免疫反应进行了分析。SSPE患者以及SAME大鼠均显示出具有MV特异性的寡克隆鞘内抗体合成。SAME大鼠在脑内合成MV特异性抗体的程度高于SSPE患者。尽管在SSPE患者以及SAME大鼠的脑脊液（CSF）中检测到MV特异性抗体的等电模式受限，但大鼠标本中免疫球蛋白带簇内的异质性更高。仅在SAME大鼠中检测到血脑屏障对白蛋白的通透性增加，而在SSPE患者中未检测到。这些数据表明，该大鼠模型为研究MV诱导性脑脊髓炎中的初始体液事件提供了绝佳机会。
