Martínez-Momblan Maria Antonia, Alonso-Fernández Sergio, Marques-Pamies Montserrat, Salinas Isabel, Vázquez Federico, Soldevila Berta, Asensio-Wandosell Diego, Ciriza Raquel, Santos Alicia, Valassi Elena, Webb Susan M, Puig-Domingo Manuel
M Martínez-Momblan, Fundamental and Clinical Nursing Department, Universitat de Barcelona, Barcelona, Spain.
S Alonso-Fernández, Fundamental and Clinical Nursing Department, Universitat de Barcelona, Barcelona, Spain.
Endocr Connect. 2025 Apr 1;14(5). doi: 10.1530/EC-24-0545.
The diagnosis of acromegaly is often delayed, leading to facial disfigurements that persist despite endocrine cure. We aimed to study the relationship between facial modifications, Quality of Life (QoL), and psychologic status in patients with acromegaly.
Sixty-five patients in remission or with hormonal disease control participated (29 women and 36 men; mean age 57.4±13.5 years). The following variables were assessed: a) Quality of life using AcroQoL; b) Anxiety level with the STAI Questionnaire; c) Self-esteem by the Rosemberg Scale; and d) Facial acromegaly phenotypic changes evaluated from photographs by 8 experienced endocrinologists using a Likert scale.
The overall AcroQoL score showed mid-range values, with better scores for men (72.3 vs 56.6, p=0.022). AcroQoL physical domain was also higher for men (59.0 vs 34.9, p=0.006). In the psychological domain, men tended to score better (65.7 vs 54.5, p=0.069), particularly in the appearance subdimension (53.8 vs 38.8, p=0.07), while women had worse anxiety scores (p=0.009). Global self-esteem was high (2.7 ± 0.6 for a maximal value of 3), without sex differences. A trend towards a negative correlation between self-esteem and facial scores was observed (rs= -0.559, p=0.074), indicating a low psychological impact.
In controlled acromegaly, QoL is relatively preserved in both genders, although men have better anxiety scores. Facial changes have a weak but persistent negative impact on psychological status, with greater intensity observed in women.
肢端肥大症的诊断常常延迟，导致面部畸形，即便内分泌功能得以治愈，这些畸形仍会持续存在。我们旨在研究肢端肥大症患者面部改变、生活质量（QoL）和心理状态之间的关系。
65例处于缓解期或激素疾病得到控制的患者参与了研究（29例女性和36例男性；平均年龄57.4±13.5岁）。评估了以下变量：a）使用肢端肥大症生活质量量表（AcroQoL）评估生活质量；b）使用状态特质焦虑问卷（STAI）评估焦虑水平；c）通过罗森伯格自尊量表评估自尊；d）由8位经验丰富的内分泌学家使用李克特量表从照片评估面部肢端肥大症的表型变化。
AcroQoL总分显示为中等范围值，男性得分更高（72.3对56.6，p=0.022）。男性在AcroQoL身体领域得分也更高（59.0对34.9，p=0.006）。在心理领域，男性得分往往更高（65.7对54.5，p=0.069），尤其是在外貌子维度（53.8对38.8，p=0.07），而女性焦虑得分更差（p=0.009）。总体自尊较高（最大值为3时为2.7±0.6），无性别差异。观察到自尊与面部得分之间存在负相关趋势（rs = -0.559，p=0.074），表明心理影响较低。
在控制良好的肢端肥大症患者中，尽管男性焦虑得分更好，但两性的生活质量相对得以保留。面部变化对心理状态有微弱但持续的负面影响，女性中观察到的影响强度更大。
