Cyuńczyk Monika, Zujko Małgorzata Elżbieta, Jamiołkowski Jacek, Zujko Kinga, Łapińska Magda, Zalewska Magdalena, Kondraciuk Marcin, Witkowska Anna Maria, Kamiński Karol Adam
Department of Food Biotechnology, Faculty of Health Sciences, Medical University of Bialystok, Szpitalna 37, 15-295 Bialystok, Poland.
Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, Waszyngtona 13a, 15-269 Bialystok, Poland.
Antioxidants (Basel). 2022 Jan 29;11(2):283. doi: 10.3390/antiox11020283.
The aim of this study was to assess the relationship between the dietary total antioxidant capacity (DTAC) and occurrence of prediabetes, diabetes and insulin resistance in the Bialystok PLUS (Polish Longitudinal University Study) population. Daily food consumption was estimated by 3-days 24-h dietary recalls. DTAC was calculated using the date of food consumption and antioxidant potential of foods measured by FRAP (ferric ion reducing antioxidant potential) method. The following measurements were performed to identify prediabetes, diabetes and HOMA-IR: fasting glucose (FG), 2h postprandial glucose level (2h-PG), fasting insulin (FI), glycated hemoglobin HbA1c. Logistic regression models were used to assess the relationship between DTAC and prediabetes and diabetes. This study demonstrated that higher quartile of DTAC, after adjustment for confounding variables, was significantly associated with a reduced odds ratio for the prevalence of prediabetes in Bialystok PLUS population aged 35-65 years. DTAC was also significantly inversely associated with HOMA-IR in multivariate linear regression model. DTAC was positively related to individual dietary antioxidants (polyphenols, antioxidant vitamins and minerals). Reduced DTAC may be considered as an additional risk factor for the development of diabetes. Therefore, dietary recommendations for prevention and therapy of diabetes should take into account the high DTAC.
本研究旨在评估比亚韦斯托克PLUS（波兰纵向大学研究）人群的膳食总抗氧化能力（DTAC）与糖尿病前期、糖尿病及胰岛素抵抗发生之间的关系。通过3天24小时膳食回顾来估计每日食物摄入量。DTAC采用食物消费数据及通过FRAP（铁离子还原抗氧化能力）法测定的食物抗氧化潜力来计算。为确定糖尿病前期、糖尿病及HOMA-IR进行了以下测量：空腹血糖（FG）、餐后2小时血糖水平（2h-PG）、空腹胰岛素（FI）、糖化血红蛋白HbA1c。采用逻辑回归模型评估DTAC与糖尿病前期及糖尿病之间的关系。本研究表明，在对混杂变量进行校正后，DTAC处于较高四分位数与35至65岁的比亚韦斯托克PLUS人群中糖尿病前期患病率的优势比降低显著相关。在多变量线性回归模型中，DTAC也与HOMA-IR显著负相关。DTAC与个体膳食抗氧化剂（多酚、抗氧化维生素和矿物质）呈正相关。DTAC降低可能被视为糖尿病发生的一个额外风险因素。因此，糖尿病预防和治疗的膳食建议应考虑高DTAC。
