光生物调节疗法在鼻中隔成形术建模期间减轻大鼠海马体中应激诱导变化的作用。
The Role of Photobiomodulation Therapy in Reducing Stress-Induced Changes in the Hippocampus of Rats during Septoplasty Modeling.
作者信息
Kotov V N, Kastyro I V, Ganshin I B, Popadyuk V I, Dragunova S G, Khodorovich O S, Kartasheva A F, Barannik M I, Sarygin P V
机构信息
Lumumba Peoples' Friendship University of Russia, Moscow, Russia.
出版信息
Dokl Biochem Biophys. 2025 Apr;521(1):187-191. doi: 10.1134/S1607672924601033. Epub 2025 Apr 11.
UNLABELLED
The aim of the study was to investigate the effect of photobiomodulation therapy (PBMT) on the amount of p53 in neurons of the pyramidal layer of the hippocampus after modeling septoplasty in rats.
MATERIALS AND METHODS
Septoplasty was modeled in 48 Wistar rats. PBMT was administered to 24 rats in the early postoperative period for 2 to 6 days. Histological sections of the hippocampus were studied to determine p53-positive neurons on days 2, 4, and 6 after surgery in rats of both groups.
RESULTS
Compared with the control group (n = 5 rats), in both experimental groups there was an increase in the number of p53-positive neurons in the hippocampus, however, in the group where PBMT was performed in the early postoperative period after modeling septoplasty, the number of such neurons was lower, and in some subfields of the hippocampus on day 6 it even corresponded to the control group.
CONCLUSIONS
The use of PBMT in the early postoperative period after modeling septoplasty helps to reduce stress-induced expression of the p53 protein in the pyramidal layer of the hippocampus in rats.
未标记
本研究的目的是调查光生物调节疗法（PBMT）对大鼠鼻中隔成形术建模后海马锥体细胞层神经元中p53含量的影响。
材料与方法
对48只Wistar大鼠进行鼻中隔成形术建模。术后早期对24只大鼠给予PBMT，持续2至6天。研究两组大鼠术后第2、4和6天海马的组织学切片，以确定p53阳性神经元。
结果
与对照组（n = 5只大鼠）相比，两个实验组海马中p53阳性神经元数量均增加，然而，在鼻中隔成形术建模后术后早期进行PBMT的组中，此类神经元数量较少，且在术后第6天海马的一些亚区甚至与对照组相当。
结论
在鼻中隔成形术建模后术后早期使用PBMT有助于降低大鼠海马锥体细胞层中应激诱导的p53蛋白表达。
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