Salehpour Farzad, Rasta Seyed Hossein
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Rev Neurosci. 2017 May 24;28(4):441-453. doi: 10.1515/revneuro-2016-0087.
Major depressive disorder is a common debilitating mood disorder that affects quality of life. Prefrontal cortex abnormalities, an imbalance in neurotransmitters, neuroinflammation, and mitochondrial dysfunction are the major factors in the etiology of major depressive disorder. Despite the efficacy of pharmacotherapy in the treatment of major depressive disorder, 30%-40% of patients do not respond to antidepressants. Given this, exploring the alternative therapies for treatment or prevention of major depressive disorder has aroused interest among scientists. Transcranial photobiomodulation therapy is the use of low-power lasers and light-emitting diodes in the far-red to near-infrared optical region for stimulation of neuronal activities. This non-invasive modality improves the metabolic capacity of neurons due to more oxygen consumption and ATP production. Beneficial effects of transcranial photobiomodulation therapy in the wide range of neurological and psychological disorders have been already shown. In this review, we focus on some issue relating to the application of photobiomodulation therapy for major depressive disorder. There is some evidence that transcranial photobiomodulation therapy using near-infrared light on 10-Hz pulsed mode appears to be a hopeful technique for treatment of major depressive disorder. However, further studies are necessary to find the safety of this method and to determine its effective treatment protocol.
重度抑郁症是一种常见的使人衰弱的情绪障碍，会影响生活质量。前额叶皮质异常、神经递质失衡、神经炎症和线粒体功能障碍是重度抑郁症病因中的主要因素。尽管药物疗法在治疗重度抑郁症方面有疗效，但30%-40%的患者对抗抑郁药无反应。鉴于此，探索治疗或预防重度抑郁症的替代疗法引起了科学家们的兴趣。经颅光生物调节疗法是利用远红外到近红外光学区域的低功率激光和发光二极管来刺激神经元活动。这种非侵入性方式由于更多的氧气消耗和ATP产生而提高了神经元的代谢能力。经颅光生物调节疗法在广泛的神经和心理障碍中的有益作用已经得到证实。在这篇综述中，我们关注与光生物调节疗法应用于重度抑郁症相关的一些问题。有证据表明，采用10赫兹脉冲模式的近红外光进行经颅光生物调节疗法似乎是治疗重度抑郁症的一种有前景的技术。然而，需要进一步研究来确定该方法的安全性并确定其有效的治疗方案。
