Veschetti Laura, Boaretti Marzia, Saitta Giulia Maria, Passarelli Mantovani Rebeca, Lleò Maria M, Sandri Angela, Malerba Giovanni
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.
Department of Diagnostics and Public Health, Microbiology Section, University of Verona, 37134 Verona, Italy.
Microbiol Res. 2022 Oct;263:127140. doi: 10.1016/j.micres.2022.127140. Epub 2022 Jul 22.
Bacteria belonging to the genus Achromobacter are widely distributed in natural environments and have been recognized as emerging pathogens for their contribution to a wide range of human infections. In particular, patients with cystic fibrosis (CF) are the subjects most frequently colonized by Achromobacter spp., which can cause persistent infections in their respiratory tract. Although many clinical aspects and pathogenic mechanisms still remain to be elucidated, Achromobacter spp. have been a source of expanding interest in recent years. This review examines the current literature regarding Achromobacter spp. role in CF, focusing on taxonomy, prevalence in CF lung infections, genomic characteristics, and adaptation strategies including modifications of metabolism and virulence, acquisition of antibiotic resistance, exchange of mobile genetic elements and development of hypermutation.
无色杆菌属细菌广泛分布于自然环境中，因其在多种人类感染中的作用而被视为新兴病原体。特别是，囊性纤维化（CF）患者是最常被无色杆菌属细菌定植的人群，这些细菌可在其呼吸道引起持续性感染。尽管许多临床方面和致病机制仍有待阐明，但无色杆菌属细菌近年来一直是人们日益关注的对象。本综述考察了关于无色杆菌属细菌在CF中作用的现有文献，重点关注分类学、在CF肺部感染中的流行情况、基因组特征以及适应策略，包括代谢和毒力的改变、抗生素耐药性的获得、移动遗传元件的交换以及超突变的发生。
