Lee Jungha, Shin Donghwi, Sung Taehoon, Kim Minha, Nam Changhoon, Son Wongyun, Lee Inhyung
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of Korea.
Animals (Basel). 2025 Mar 27;15(7):973. doi: 10.3390/ani15070973.
This prospective, non-blinded study assessed the performance of a portable anesthesia machine with an oxygen concentrator (PAM) across various oxygen flow rates and vaporizer settings, incorporating both in vitro and in vivo experiments. The oxygen delivery test measured the time required to reach 90% fraction of inspired oxygen (FIO) at various flow rates. The vaporizer test assessed the time to stabilize maximum fraction of inspired isoflurane (FIIso) concentration at various oxygen flow rate and vaporizer settings. In the in vivo test, six adult male Beagle dogs (11.4 ± 1.4 kg) were evaluated. The in vivo evaluation included monitoring physiological parameters during isoflurane anesthesia. The higher flow rates significantly reduced the time to plateau for FIO ( < 0.001). Maximum FIIso values were lower than the vaporizer dial settings, and increased oxygen flow rates significantly reduced the time required to reach target values ( < 0.001). Physiological parameters remained stable throughout anesthesia, confirming adequate oxygenation and anesthetic maintenance. The PAMoc, despite its lower pounds per square inch, yielded predictable outcomes consistent with those obtained in conventional anesthesia systems. These results demonstrated the viability of the PAMoc for anesthesia administration in the field and other challenging environments.
这项前瞻性、非盲法研究评估了配备氧气浓缩器的便携式麻醉机（PAM）在各种氧流量和蒸发器设置下的性能，包括体外和体内实验。氧气输送测试测量了在各种流速下达到吸入氧分数（FIO）90%所需的时间。蒸发器测试评估了在各种氧流量和蒸发器设置下稳定吸入异氟烷最大分数（FIIso）浓度所需的时间。在体内测试中，对6只成年雄性比格犬（11.4±1.4千克）进行了评估。体内评估包括在异氟烷麻醉期间监测生理参数。较高的流速显著缩短了FIO达到平稳状态的时间（<0.001）。最大FIIso值低于蒸发器刻度盘设置，增加氧流量显著缩短了达到目标值所需的时间（<0.001）。整个麻醉过程中生理参数保持稳定，证实了充分的氧合和麻醉维持。尽管PAMoc的每平方英寸磅数较低，但其产生的可预测结果与传统麻醉系统获得的结果一致。这些结果证明了PAMoc在野外和其他具有挑战性的环境中进行麻醉给药的可行性。
