Department of Orthopedic Surgery and Traumatology, University Hospital of Lausanne, CH-1011 Lausanne, Switzerland.
Laboratory of Biomechanical Orthopaedics, Institute of Bioengineering, School of Engineering, EPFL, CH-1015 Lausanne, Switzerland.
Int J Mol Sci. 2024 Sep 16;25(18):9984. doi: 10.3390/ijms25189984.
Cartilage repair remains a major challenge in human orthopedic medicine, necessitating the application of innovative strategies to overcome existing technical and clinical limitations. Adhesive hydrogels have emerged as promising candidates for cartilage repair promotion and tissue engineering, offering key advantages such as enhanced tissue integration and therapeutic potential. This comprehensive review navigates the landscape of adhesive hydrogels in cartilage repair, discussing identified challenges, shortcomings of current treatment options, and unique advantages of adhesive hydrogel products and scaffolds. While emphasizing the critical need for in situ lateral integration with surrounding tissues, we dissect current limitations and outline future perspectives for hydrogel scaffolds in cartilage repair. Moreover, we examine the clinical translation pathway and regulatory considerations specific to adhesive hydrogels. Overall, this review synthesizes the existing insights and knowledge gaps and highlights directions for future research regarding adhesive hydrogel-based devices in advancing cartilage tissue engineering.
软骨修复仍然是人类矫形医学的主要挑战，需要应用创新策略来克服现有技术和临床的局限性。黏附性水凝胶已成为促进软骨修复和组织工程的有前途的候选材料，具有增强组织整合和治疗潜力等关键优势。本综述全面探讨了黏附性水凝胶在软骨修复中的应用，讨论了已确定的挑战、当前治疗方案的缺点以及黏附性水凝胶产品和支架的独特优势。在强调与周围组织进行原位侧向整合的重要性的同时，我们剖析了当前的局限性，并为水凝胶支架在软骨修复中的未来发展方向提供了展望。此外，我们还研究了黏附性水凝胶的临床转化途径和监管考虑因素。总的来说，本综述综合了现有的见解和知识空白，并强调了未来在基于黏附性水凝胶的装置在推进软骨组织工程方面的研究方向。
