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使用活化部分凝血活酶时间和凝血酶原时间评估新鲜冰冻血浆的质量。

Use of activated partial thrombin time and prothrombin time for quality assessment of fresh frozen plasma.

作者信息

Layibo Yao, Padaro Essohana, Magnang Hèzouwè, Badassan Magnime, Kuéviakoé Irenée M D, Mawussi Koffi, Fétéké Lochina

机构信息

National Institute of Hygiene, Lome, Togo.

Department of Health Sciences, University of Lome, Lome, Togo.

出版信息

Int J Hematol. 2025 Apr 12. doi: 10.1007/s12185-025-03984-4.

Abstract

The aim of this study was to evaluate the usefulness of activated partial thromboplastin time (APTT) and prothrombin time (PT) for determining the quality of fresh frozen plasma (FFP) units in low-income countries. Quality control was conducted for 66 randomly selected FFP units after 3 months of freezing at - 20 °C. The average volume of the FFP units was 177.8 ± 17.3 mL, with average concentrations of 79.9 ± 40.2 IU/dL for factor VIII, 83.4 ± 29.3 IU/dL for factor IX, and 2.3 ± 0.7 g/L for fibrinogen. Fifty-six percent of the FFP units had a factor VIII level greater than or equal to 70 IU/dL. Unlike PT, the PT ratio, and the international normalized ratio, both APTT and the APTT ratio provided useful information regarding factor VIII level compliance, with areas under the curve of 71% and 73%, respectively. The optimal cutoff values for FFP unit compliance assessment were 40 s for APTT and 1.23 for the APTT ratio. Accuracy rates were 65% and 70%, with Cohen's kappa coefficients of 0.31 and 0.40 for the APTT and APTT ratios, respectively. APTT outperformed PT, and showed fair to moderate agreement with factor VIII level compliance in FFP units.

摘要

本研究的目的是评估活化部分凝血活酶时间(APTT)和凝血酶原时间(PT)在低收入国家用于确定新鲜冰冻血浆(FFP)单位质量的有用性。在-20°C冷冻3个月后,对66个随机选择的FFP单位进行了质量控制。FFP单位的平均体积为177.8±17.3 mL,因子VIII的平均浓度为79.9±40.2 IU/dL,因子IX的平均浓度为83.4±29.3 IU/dL,纤维蛋白原的平均浓度为2.3±0.7 g/L。56%的FFP单位因子VIII水平大于或等于70 IU/dL。与PT、PT比值和国际标准化比值不同,APTT和APTT比值均提供了有关因子VIII水平合规性的有用信息,曲线下面积分别为71%和73%。FFP单位合规性评估的最佳临界值为APTT 40秒,APTT比值为1.23。准确率分别为65%和70%,APTT和APTT比值的Cohen's kappa系数分别为0.31和0.40。APTT优于PT,并且与FFP单位中因子VIII水平合规性表现出一般到中等程度的一致性。

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