Ramaut Lisa, Hoeksema Henk, Pirayesh Ali, Stillaert Filip, Monstrey Stan
University Hospital of Ghent, De Pintelaan 185, 9000 Ghent, Belgium.
Department of Plastic and Reconstructive Surgery - Burn Center, University Hospital of Ghent, De Pintelaan 185, 9000 Ghent, Belgium.
J Plast Reconstr Aesthet Surg. 2018 Jan;71(1):1-14. doi: 10.1016/j.bjps.2017.06.006. Epub 2017 Jun 17.
Patients who suffer from scars or wrinkles have several therapeutic options to improve the appearance of their skin. The available treatment modalities that provide desirable results are often overtly invasive and entail a risk of undesirable adverse effects. Microneedling has recently emerged as a non-ablative alternative for treating patients who are concerned with the aesthetic changes that result from injury, disease or ageing.
This review aims to evaluate the current evidence in the literature on microneedling.
A systematic literature review was performed by searching the electronic databases PubMed and Google Scholar. The reviewed articles were analysed and compared on study design, treatment protocol, outcome parameters, efficacy measurement and results to evaluate the strength of the current evidence.
Microneedling was investigated in experimental settings for its effects on atrophic acne scars, skin rejuvenation, hypertrophic scars, keloids, striae distensae, androgenetic alopecia, melasma and acne vulgaris. Several clinical trials used randomisation and single-blindation to strengthen the validity of the study outcome. Microneedling showed noteworthy results when used on its own and when combined with topical products or radiofrequency. When compared with other treatments, it showed similar results but was preferred due to minimal side effects and shorter downtime.
This systematic review positions microneedling as a safe and effective therapeutic option for the treatment of scars and wrinkles. The current literature does show some methodological shortcomings, and further research is required to truly establish microneedling as an evidence-based therapeutic option for treating scars, wrinkles and other skin conditions.
患有疤痕或皱纹的患者有多种治疗选择来改善皮肤外观。能产生理想效果的现有治疗方式往往具有明显的侵入性，且存在产生不良副作用的风险。微针疗法最近已成为一种非剥脱性替代方法，用于治疗那些关注因损伤、疾病或衰老导致的美学变化的患者。
本综述旨在评估文献中关于微针疗法的现有证据。
通过检索电子数据库PubMed和谷歌学术进行系统的文献综述。对纳入综述的文章在研究设计、治疗方案、结果参数、疗效测量和结果等方面进行分析和比较，以评估现有证据的力度。
在实验环境中研究了微针疗法对萎缩性痤疮疤痕、皮肤年轻化、增生性疤痕、瘢痕疙瘩、膨胀纹、雄激素性脱发、黄褐斑和寻常痤疮的影响。一些临床试验采用随机化和单盲法来增强研究结果的有效性。微针疗法单独使用以及与局部产品或射频联合使用时均显示出显著效果。与其他治疗方法相比，它显示出相似的效果，但因副作用最小且恢复时间较短而更受青睐。
本系统综述将微针疗法定位为治疗疤痕和皱纹的一种安全有效的治疗选择。当前文献确实显示出一些方法学上的不足，需要进一步研究才能真正将微针疗法确立为治疗疤痕、皱纹及其他皮肤病症的循证治疗选择。
