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The genetic architecture of type 1 diabetes over time: how well can we rely on past data to predict the future?1型糖尿病随时间变化的遗传结构：我们能在多大程度上依靠过去的数据来预测未来？
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本文引用的文献

1
Incidence of Type 1 Diabetes in Children Has Fallen to Pre-COVID-19 Pandemic Levels: A Population-Wide Analysis From Scotland.儿童1型糖尿病发病率已降至新冠疫情前水平：来自苏格兰的全人群分析
Diabetes Care. 2024 Mar 1;47(3):e26-e28. doi: 10.2337/dc23-2068.
2
A classification and regression tree analysis identifies subgroups of childhood type 1 diabetes.分类回归树分析可确定儿童 1 型糖尿病的亚组。
EBioMedicine. 2022 Aug;82:104118. doi: 10.1016/j.ebiom.2022.104118. Epub 2022 Jul 5.
3
Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.精细映射、跨祖先和基因组分析确定了 1 型糖尿病的因果变异、细胞、基因和药物靶点。
Nat Genet. 2021 Jul;53(7):962-971. doi: 10.1038/s41588-021-00880-5. Epub 2021 Jun 14.
4
Update on Worldwide Trends in Occurrence of Childhood Type 1 Diabetes in 2020.2020年全球儿童1型糖尿病发病趋势最新情况
Pediatr Endocrinol Rev. 2020 Mar;17(Suppl 1):198-209. doi: 10.17458/per.vol17.2020.tol.epidemiologychildtype1diabetes.
5
Identification of infants with increased type 1 diabetes genetic risk for enrollment into Primary Prevention Trials-GPPAD-02 study design and first results.为将患 1 型糖尿病风险较高的婴儿纳入原发性预防试验（GPPAD-02 研究）而进行的婴儿鉴定-研究设计和初步结果。
Pediatr Diabetes. 2019 Sep;20(6):720-727. doi: 10.1111/pedi.12870. Epub 2019 Jun 13.
6
Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis.改良的 1 型糖尿病遗传风险评分的制定与标准化：用于新生儿筛查和发病诊断。
Diabetes Care. 2019 Feb;42(2):200-207. doi: 10.2337/dc18-1785.
7
Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections.全基因组关联研究和HLA区域精细定位研究确定了多种常见感染的易感基因座。
Nat Commun. 2017 Sep 19;8(1):599. doi: 10.1038/s41467-017-00257-5.
8
The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes.儿童1型糖尿病发病率的上升以及高危HLA单倍型贡献的降低。
Lancet. 2004;364(9446):1699-700. doi: 10.1016/S0140-6736(04)17357-1.
9
IDDM2/insulin VNTR modifies risk conferred by IDDM1/HLA for development of Type 1 diabetes and associated autoimmunity.IDDM2/胰岛素可变数目串联重复序列改变了由IDDM1/ HLA所赋予的1型糖尿病发生及相关自身免疫的风险。
Diabetologia. 2003 May;46(5):712-20. doi: 10.1007/s00125-003-1082-z. Epub 2003 May 16.

The genetic architecture of type 1 diabetes over time: how well can we rely on past data to predict the future?

作者信息

Zapardiel-Gonzalo Jose, Ziegler Anette-Gabriele, Bonifacio Ezio

机构信息

Institute of Diabetes Research, Helmholtz Munich, German Research Center for Environmental Health, Munich, Germany.

Center for Regenerative Therapies Dresden, Faculty of Medicine, TU Dresden, Dresden, Germany.

出版信息

Diabetologia. 2025 Jun;68(6):1352-1354. doi: 10.1007/s00125-025-06422-6. Epub 2025 Apr 12.

DOI:10.1007/s00125-025-06422-6
PMID:40220192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12069405/
Abstract
摘要