Levitt S H, McHugh R B
Cancer. 1977 Feb;39(2 Suppl):924-32. doi: 10.1002/1097-0142(197702)39:2+<924::aid-cncr2820390731>3.0.co;2-7.
A statistical assessment of several "randomized" clinical trials was carried out and the following conclusions were noted. 1. There is no statistically significant evidence that radiation to the peripheral lymphatics and/or chest wall following radical mastectomy affects survival. 2. There is significant evidence that postoperative irradiation to the peripheral lymphatics and/or chest wall does decrease local recurrence rate. 3. There is reliable evidence that the treatment of local recurrence, once it develops, is successful in only 50% of the cases. 4. There is evidence that radiation plus simple mastectomy is as effective in the treatment of breast cancer as radical mastectomy alone. It is our considered opinion that radiation remains a useful adjuvant and complementary agent in the treatment of breast cancer, is not harmful vis a vis survival and should be used when and where indicated.
对几项“随机”临床试验进行了统计学评估，并得出以下结论。1. 没有统计学上的显著证据表明根治性乳房切除术后对周围淋巴管和/或胸壁进行放疗会影响生存率。2. 有显著证据表明，术后对周围淋巴管和/或胸壁进行放疗确实会降低局部复发率。3. 有可靠证据表明，一旦发生局部复发，治疗仅在50%的病例中成功。4. 有证据表明，放疗加单纯乳房切除术在治疗乳腺癌方面与单纯根治性乳房切除术一样有效。我们经过深思熟虑后认为，放疗仍然是治疗乳腺癌的一种有用的辅助和补充手段，对生存率无害，应在有指征时使用。
