Loring D W, Largen J W
Neuropsychologia. 1985;23(3):351-7. doi: 10.1016/0028-3932(85)90021-1.
Thirty-seven patients with a presumptive diagnosis of dementia of the Alzheimer type were divided into presenile and senile groups according to the age at which they first received a clinical diagnosis. Although there were no differences in mental status, dementia rating, or chronicity of disease, multivariate analyses of WAIS subtests revealed the presenile subjects to be relatively impaired on Performance subtests. Univariate tests of Verbal, Performance, and Full Scale IQ measures were significantly lower in the presenile group. There was no group effect detected for Digits forward, adjusted for age differences based upon performance of 40 age-matched controls, while the presenile group performed significantly more poorly on backward span. Further, significant differences were detected for an embedded figure task, as well as graphomotor speed. These data suggest that patients who develop a degenerative dementia during the presenile period are more impaired than their senile counterparts on age-adjusted measures of sustained concentration and mental tracking.
37例初步诊断为阿尔茨海默型痴呆的患者，根据首次临床诊断时的年龄分为早老性和老年性两组。尽管在精神状态、痴呆评分或病程方面没有差异，但对韦氏成人智力量表（WAIS）子测验的多变量分析显示，早老性患者在操作性子测验中相对受损。言语、操作和全量表智商测量的单变量检验在早老性组中显著更低。根据40名年龄匹配对照的表现对年龄差异进行校正后，顺背数字未检测到组间效应，而早老性组在倒背跨度上表现明显更差。此外，在镶嵌图形任务以及书写运动速度方面检测到显著差异。这些数据表明，在早老期发生退行性痴呆的患者，在年龄校正的持续注意力和心理追踪测量中，比老年性患者受损更严重。
