Irle E, Kessler J, Markowitsch H J, Hofmann W
Department of Psychology, University of Heidelberg, Federal Republic of Germany.
Brain Cogn. 1987 Oct;6(4):429-49. doi: 10.1016/0278-2626(87)90138-2.
Eight subjects with the likely diagnosis of presenile or senile dementia of the Alzheimer type were tested on two frequently used primate learning tasks: a concurrent object discrimination task and a delayed non-match-to-sample task. In addition, various tests for cognitive, mnemonic, perceptual, and language functions were applied. The results suggest a severe decline of the Alzheimer subjects in all measures when compared with 10 control subjects matched for age, gender, and education. The two animal learning tasks revealed strong impairments, thus demonstrating a high sensitivity for the detection and assessment of human amnesic disorders. Implications of these findings for human neuropsychological, and especially comparative neuropsychological, research are discussed.
同时进行的物体辨别任务和延迟非匹配样本任务。此外，还应用了各种认知、记忆、感知和语言功能测试。结果表明，与10名年龄、性别和教育程度相匹配的对照受试者相比，阿尔茨海默病受试者在所有测量指标上均有严重下降。这两项动物学习任务显示出严重受损，从而证明了其对检测和评估人类失忆症的高敏感性。讨论了这些发现对人类神经心理学，尤其是比较神经心理学研究的意义。
