Rizzi Nicholas A, Kramer Mary K, DeConne Theodore M, Ellison James M, Lanzi Alyssa M, Overstreet Matthew L, Edwards David G, Cohen Matthew L, Johnson Curtis L, Martens Christopher R
Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, USA.
Department of Biomedical Engineering, University of Delaware, Newark, Delaware, USA.
Physiol Rep. 2025 Apr;13(7):e70326. doi: 10.14814/phy2.70326.
Previous studies in individuals with mild cognitive impairment suggest that they may have altered systemic metabolic function at rest; however, metabolic function during aerobic exercise is not fully understood in this population. This study sought to determine whether individuals with amnestic mild cognitive impairment (aMCI) have lower rates of baseline and peak fat oxidation (FatOx) during a graded exercise test (GXT) compared with cognitively unimpaired control participants (CU). Twenty-two (22) older adults with aMCI and 21 age- and sex-matched adults completed a GXT to assess rates of substrate oxidation and peak oxygen consumption (VO peak). Rates of FatOx and carbohydrate oxidation (CHOOx) were assessed using VO and VCO. Resting absolute (0.10 ± 0.03 vs. 0.09 ± 0.02 g/min, p = 0.126) and relative (1.5 ± 0.43 vs. 1.4 ± 0.44 mg/kg/min, p = 0.492) rates of FatOx, as well as resting absolute (0.51 ± 0.11 vs. 0.59 ± 0.15 g/min, p = 0.093) and relative (8.0 ± 2.3 vs. 7.5 ± 2.7 mg/kg/min, p = 0.126) rates of CHOOx were similar between groups. However, peak absolute rates of FatOx (0.33 ± 0.13 vs. 0.39 ± 0.10 g/min, p = 0.033) and CHOOx (1.9 ± 0.41 vs. 2.2 ± 0.49 g/min, p = 0.046) were significantly lower in the aMCI group. Time to fatigue (7.2 ± 2.0 vs. 8.7 ± 2.3 min, p = 0.033) and absolute VO peak (1.3 ± 0.34 vs. 1.6 ± 0.47 L/min, p = 0.024) were also significantly lower in the aMCI group. These findings suggest that absolute peak rates of whole-body FatOx and CHOOx are reduced during aerobic exercise in older adults with aMCI.
先前针对轻度认知障碍个体的研究表明，他们在静息状态下可能存在全身代谢功能改变；然而，该人群有氧运动期间的代谢功能尚未完全明确。本研究旨在确定与认知未受损的对照参与者（CU）相比，遗忘型轻度认知障碍（aMCI）个体在分级运动试验（GXT）期间的基线和峰值脂肪氧化（FatOx）率是否更低。22名患有aMCI的老年人和21名年龄及性别匹配的成年人完成了一项GXT，以评估底物氧化率和峰值耗氧量（VO峰值）。使用VO和VCO评估FatOx和碳水化合物氧化（CHOOx）率。两组之间的静息绝对FatOx率（0.10±0.03 vs. 0.09±0.02 g/min，p = 0.126）和相对FatOx率（1.5±0.43 vs. 1.4±0.44 mg/kg/min，p = 0.492），以及静息绝对CHOOx率（0.51±0.11 vs. 0.59±0.15 g/min，p = 0.093）和相对CHOOx率（8.0±2.3 vs. 7.5±2.7 mg/kg/min，p = ？）相似。然而，aMCI组的峰值绝对FatOx率（0.33±0.13 vs. 0.39±0.10 g/min，p = 0.033）和CHOOx率（1.9±0.41 vs. 2.2±0.49 g/min，p = 0.046）显著更低。疲劳时间（7.2±2.0 vs. 8.7±2.3 min，p = 0.033）和绝对VO峰值（1.3±0.34 vs. 1.6±0.47 L/min，p = 0.024）在aMCI组中也显著更低。这些发现表明患有aMCI的老年人在有氧运动期间全身FatOx和CHOOx的绝对峰值率降低。 （注：原文中相对CHOOx率对比的p值缺失）
