He Jiahao, Li Jie, Ren Jinliang, Cao Xiaona, Xu Ting, Liang Chaofeng, Zhuang Bowen, Lin Xudong, Li Ningning, Xu Bingzhe
School of Biomedical Engineering, Sun Yat-sen University, No. 135, Xingang Xi Road, Guangzhou, 510275, P. R. China.
School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, No.66, Gongchang Road, Guangming District, Shenzhen, 518107, P. R. China.
Adv Healthc Mater. 2025 Jun;14(15):e2404918. doi: 10.1002/adhm.202404918. Epub 2025 Apr 13.
Implantable devices that integrate advanced nanomaterials with wireless energy systems represent a transformative approach to tackling brain tumors. Here, a millimeter-scale implantable device based on an MXene/polyvinyl alcohol (PVA) hydrogel is introduced, designed for precise and minimally invasive brain tumor therapy via tunable alternating electric fields. This device presents a novel approach by combining ultrasonic wireless energy transfer with triboelectric energy harvesting, eliminating the need for in vivo batteries and enabling continuous operation in a completely wireless manner. The system not only optimizes energy harvesting efficiency but also ensures the localized delivery of therapeutic electric fields directly to the tumor site. Its compact size and mechanical flexibility allow for precise implantation in the complex brain environment, offering a minimally invasive solution with enhanced safety and adaptability. Preclinical evaluations using U-87 MG orthotopic glioblastoma models demonstrate significant tumor growth inhibition and a marked improvement in survival rates, underscoring its therapeutic potential.
将先进纳米材料与无线能量系统相结合的可植入设备，代表了一种治疗脑肿瘤的变革性方法。在此，介绍一种基于MXene/聚乙烯醇（PVA）水凝胶的毫米级可植入设备，其设计用于通过可调交变电场进行精确且微创的脑肿瘤治疗。该设备通过将超声无线能量传输与摩擦电能量收集相结合，提出了一种新颖的方法，无需体内电池，并能以完全无线的方式实现连续运行。该系统不仅优化了能量收集效率，还确保了治疗电场直接局部递送至肿瘤部位。其紧凑的尺寸和机械灵活性允许在复杂的脑环境中精确植入，提供了一种具有更高安全性和适应性的微创解决方案。使用U-87 MG原位胶质母细胞瘤模型进行的临床前评估表明，该设备具有显著的肿瘤生长抑制作用，并显著提高了生存率，突出了其治疗潜力。
