Hu Xiaoping, Qiu Ziyi, Yang Yilin, Xu Ting, Sheng Kai, Lu Weicheng, Xie Jingdun, Xu Bingzhe
School of Biomedical Engineering, Sun Yat-sen University, No. 135, Xingang Xi Road, Guangzhou, 510275, P. R. China.
School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, No.66, Gongchang Road, Guangming District, Shenzhen, 518107, P. R. China.
Adv Sci (Weinh). 2025 Feb;12(5):e2309610. doi: 10.1002/advs.202309610. Epub 2024 Dec 12.
Glioblastoma (GBM) is a lethal disease with a poor prognosis due to its strong infiltration, which makes it difficult to remove completely. In this study, an implantable, modulus-tunable, and ultrasound-powered MXene/PVA hydrogel-based tumor treatment device (UP-MPH-TTD), which generates specific electromagnetic alternating fields that disrupt the mitosis of cancer cells without adversely affecting normal neurons is developed. The MXene/PVA hydrogel is used to form a tumor treatment field due to its high biocompatibility, excellent flexibility, and high conductivity, which improves ultrasonic electrical conversion efficiency and significantly reduces the size of the equipment. The implantable UP-MPH-TTD is wirelessly ultrasound-powered, small-sized, lightweight, and simply structured, significantly boosting therapeutic efficiency and reducing restrictions on patient movement. In vitro and in vivo experiments confirmed the device's therapeutic effect, demonstrating a ≈92% inhibition rate in the growth of clinical tumor cells and a 73% reduction in tumor area in tumor-bearing mice. The promising results indicate the broad application potential of the device in the treatment and prognostic improvement of GBM.
胶质母细胞瘤（GBM）是一种致命疾病，因其浸润性强，预后较差，难以完全切除。在本研究中，开发了一种基于可植入、模量可调且由超声驱动的MXene/PVA水凝胶的肿瘤治疗装置（UP-MPH-TTD），该装置能产生特定的交变电磁场，干扰癌细胞的有丝分裂，同时不会对正常神经元产生不利影响。MXene/PVA水凝胶因其高生物相容性、出色的柔韧性和高导电性而被用于形成肿瘤治疗场，提高了超声电转换效率，并显著减小了设备尺寸。可植入的UP-MPH-TTD由无线超声供电，体积小、重量轻且结构简单，显著提高了治疗效率，并减少了对患者活动的限制。体外和体内实验证实了该装置的治疗效果，临床肿瘤细胞生长抑制率约为92%，荷瘤小鼠的肿瘤面积减少了73%。这些有前景的结果表明该装置在GBM治疗和改善预后方面具有广阔的应用潜力。
