Pawar Pradip, Prabhu Arati
SVKM's Dr. Bhanuben Nanavati College of Pharmacy, 400056 Mumbai, India.
Mol Pharm. 2025 May 5;22(5):2372-2391. doi: 10.1021/acs.molpharmaceut.5c00411. Epub 2025 Apr 14.
Despite significant advancements in anticancer research, the performance statistics of current therapeutic regimens yield unsatisfactory outcomes. Issues such as high metastasis rates, drug resistance, limited efficacy, and severe side effects underscore the urgent need for safer and more effective strategies for tumor mitigation. One promising approach lies in the use of superparamagnetic iron oxide nanoparticles (SPIONs) for hybridized cancer therapy, leveraging their unique properties and functional versatility to enhance treatment efficacy and safety. They can serve as platforms for various therapeutic as well as diagnostic applications, enhancing imaging techniques such as magnetic resonance imaging. This paper presents an in-depth compilation of the application of nanoparticulate SPIONs amalgamates for multimodal cancer therapeutics. Physical phenomena such as light, heat, sound, and magnetism can be coupled to nanoparticulate delivery systems for developing targeted, precision medicine against cancer. Integration of noninvasive and effective platforms technologies such as photodynamic therapy, photothermal therapy, magnetic hyperthermia, and sonodynamic therapy hold great promise in counteracting the daunting challenges within cancer therapeutics.
尽管抗癌研究取得了重大进展，但当前治疗方案的性能统计结果仍不尽人意。高转移率、耐药性、疗效有限和严重副作用等问题凸显了迫切需要更安全、更有效的肿瘤缓解策略。一种有前景的方法是使用超顺磁性氧化铁纳米颗粒（SPIONs）进行杂交癌症治疗，利用其独特的性质和功能多样性来提高治疗效果和安全性。它们可作为各种治疗和诊断应用的平台，增强诸如磁共振成像等成像技术。本文深入汇编了纳米颗粒SPIONs混合物在多模态癌症治疗中的应用。光、热、声和磁等物理现象可与纳米颗粒递送系统相结合，以开发针对癌症的靶向、精准药物。将光动力疗法、光热疗法、磁热疗和超声动力疗法等非侵入性且有效的平台技术整合起来，在应对癌症治疗中艰巨挑战方面具有巨大潜力。
