Yue Jing, Shui Huili, Li Gao, Yang Bing, Tang Dongxin
The First Clinical Medical School of Guizhou University of Traditional Chinese Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, People's Republic of China.
Department of Oncology, First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, People's Republic of China.
J Multidiscip Healthc. 2025 Apr 7;18:1895-1911. doi: 10.2147/JMDH.S507187. eCollection 2025.
This study seeks to investigate the key research hotspots and evolving trends in chemotherapy-induced bone marrow suppression over the past two decades by employing bibliometric visualization analysis, thereby providing a robust theoretical and empirical foundation for advancements in both scientific understanding and clinical practice.
Utilizing the Web of Science Core Database, a total of 6,110 documents were retrieved and analyzed using CiteSpace and VOSviewer software. This analysis traces and evaluates the current research status, key advancements, and development trajectories of chemotherapy-induced bone marrow suppression research from 2004 to 2023.
The analysis included 6,110 documents, revealing a significant upward trend in research volume. The United States (1,688 papers) and China (1,528 papers) are the leading contributors, with being the most prolific journal. Keyword burst detection identified key research focuses, including nasopharyngeal carcinoma, immunotherapy, and agents such as nivolumab and pembrolizumab. These findings indicate promising directions for further exploration, such as immunotherapy for nasopharyngeal carcinoma and innovative strategies for managing bone marrow suppression with specific drugs.
Future research may concentrate on immune checkpoint inhibitors and nasopharyngeal carcinoma. Additionally, new treatment such as the natural compound curcumin has demonstrated protective effects during chemotherapy, effectively alleviating side effects. Nutritional support strategies significantly enhance patients' quality of life during treatment, while integrative approaches that combine traditional Chinese medicine with modern medical practices reveal the potential for synergistic effects. Together, these strategies could improve clinical outcomes and effectively address the challenges posed by chemotherapy-induced bone marrow suppression.
本研究旨在通过文献计量可视化分析，探究过去二十年化疗所致骨髓抑制的关键研究热点和演变趋势，从而为科学认知和临床实践的进步提供坚实的理论和实证基础。
利用科学网核心数据库，共检索到6110篇文献，并使用CiteSpace和VOSviewer软件进行分析。该分析追溯并评估了2004年至2023年化疗所致骨髓抑制研究的当前研究状况、关键进展和发展轨迹。
分析包括6110篇文献，显示研究量呈显著上升趋势。美国（1688篇论文）和中国（1528篇论文）是主要贡献者， 是发文量最多的期刊。关键词突现检测确定了关键研究重点，包括鼻咽癌、免疫疗法以及纳武单抗和派姆单抗等药物。这些发现为进一步探索指明了有前景的方向，例如鼻咽癌的免疫疗法以及用特定药物管理骨髓抑制的创新策略。
未来研究可能集中在免疫检查点抑制剂和鼻咽癌上。此外，天然化合物姜黄素等新疗法在化疗期间已显示出保护作用，有效减轻了副作用。营养支持策略显著提高了患者治疗期间的生活质量，而将中医与现代医学实践相结合的综合方法显示出协同效应的潜力。这些策略共同作用可改善临床结果，并有效应对化疗所致骨髓抑制带来的挑战。
