Ross Luke, Carey Kelsey, Koenigsberg Robert
Radiology, Temple University Hospital, Philadelphia, USA.
Neuroradiology, Temple University Hospital, Philadelphia, USA.
Cureus. 2025 Mar 12;17(3):e80464. doi: 10.7759/cureus.80464. eCollection 2025 Mar.
Central nervous system metastases from endometrial carcinoma are a rare occurrence and suggest that metastatic endometrial carcinoma can have variable presentations. In this case report, we present three separate cases of patients diagnosed with endometrial carcinoma with metastasis to the central nervous system. The first case presents a woman with grade 2 endometrioid adenocarcinoma with mucinous and clear cell features found later to have skull metastasis with extradural extension. The second case presents a patient with an endometrial yolk sac tumor who, years after her primary diagnosis, was found to have metastasis to the brain. The final case is a woman with endometrial adenocarcinoma who developed brain metastases. While rare, it is important to consider the possibility of the presence of distal bone and brain metastases in patients with endometrial carcinoma. Special attention must be given when these patients report new neurologic symptoms, and one must consider early brain imaging.
子宫内膜癌的中枢神经系统转移较为罕见，提示转移性子宫内膜癌可能有多种表现形式。在本病例报告中，我们展示了3例分别被诊断为子宫内膜癌并发生中枢神经系统转移的患者。第一例是一名患有2级子宫内膜样腺癌且具有黏液性和透明细胞特征的女性，后来发现有颅骨转移并伴有硬膜外扩展。第二例是一名患有子宫内膜卵黄囊瘤的患者，在初次诊断多年后被发现发生了脑转移。最后一例是一名患有子宫内膜腺癌的女性，出现了脑转移。虽然罕见，但对于子宫内膜癌患者，必须考虑存在远处骨骼和脑转移的可能性。当这些患者报告新的神经系统症状时，必须给予特别关注，并且必须考虑早期进行脑部影像学检查。
