Palliative Care Unit, Chair of Oncology, Medical University of Lodz, Poland.
Arch Med Sci. 2010 Dec;6(6):937-44. doi: 10.5114/aoms.2010.19305. Epub 2010 Dec 29.
To establish risk factors for onset and progression of endometrioid endometrial cancer still remains the aim of scientists. The aim of the study was to determine disease-free survival (DFS) and overall survival (OS) in women with endometrioid endometrial cancer.
A retrospective review of 142 patients with endometrioid endometrial cancer after surgery treated with adjuvant radiotherapy and/or chemotherapy in the Regional Cancer Centre in Lodz between 2002 and 2004 was performed. Clinical and pathological data were correlated with clinical outcome and survival.
In 3 patients (2.1%) clinical progression was diagnosed during the treatment. In 23 patients (16.7%) after primary remission, relapse was diagnosed 2-56 months after treatment. DFS and OS were 81.7% and 83.1% respectively. Better DFS significantly correlated with larger number of pregnancies (> 1), stage I of the disease and optimal surgery. Lower stage of disease, pelvic lymph node dissection, optimal surgery and depth of myometrial infiltration ≤ 50% were independent prognostic factors for better OS.
The results of our study provided significant evidence that early detection of endometrioid endometrial cancer enables optimal surgery. It reduces the indications for adjuvant therapy in stage I of the disease, and makes the prognosis significantly better. Other clinical and pathological factors such as numerous pregnancies, pelvic lymphadenectomy, and depth of myometrial infiltration, although important, are of less significance. Further prospective, randomized studies are necessary to prove the role of these factors.
确定子宫内膜样型子宫内膜癌发病和进展的风险因素仍然是科学家们的目标。本研究旨在确定接受辅助放疗和/或化疗的子宫内膜样型子宫内膜癌女性的无病生存（DFS）和总生存（OS）。
对 2002 年至 2004 年期间在罗兹地区癌症中心接受手术治疗后接受辅助放疗和/或化疗的 142 例子宫内膜样型子宫内膜癌患者进行回顾性分析。将临床和病理数据与临床结果和生存相关联。
在 3 名患者（2.1%）中，在治疗过程中诊断出临床进展。在 23 名患者（16.7%）在初次缓解后，在治疗后 2-56 个月诊断出复发。DFS 和 OS 分别为 81.7%和 83.1%。DFS 更好与更多的妊娠次数（>1）、疾病 I 期和最佳手术显著相关。更好的 OS 与较低的疾病分期、盆腔淋巴结清扫术、最佳手术和肌层浸润深度≤50%独立相关。
我们的研究结果提供了重要证据，表明早期发现子宫内膜样型子宫内膜癌可实现最佳手术。这减少了疾病 I 期辅助治疗的指征，并显著改善了预后。其他临床和病理因素，如多次妊娠、盆腔淋巴结切除术和肌层浸润深度，虽然重要，但意义较小。有必要进行进一步的前瞻性、随机研究以证明这些因素的作用。
