Zhang Yuanyuan, Gan Xiaoqin, Zhou Chun, Ye Ziliang, He Panpan, Liu Mengyi, Zhang Yanjun, Yang Sisi, Qin Xianhui
Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou 510515, China.
Depress Anxiety. 2024 Oct 23;2024:6863037. doi: 10.1155/2024/6863037. eCollection 2024.
The relationship between laxative use and the risk of depression remains uncertain. We aimed to assess the prospective association of regular laxative use with the risk of incident depression and to examine whether genetic risk of depression modifies this association. Four hundred fifty thousand forty-five participants without depression at baseline and have complete information on laxative use from the UK Biobank were included. The study outcome was incident depression, derived from linkage to primary care records, hospital inpatient data, death register records, or self-reported medical conditions at follow-up visits. During a median follow-up of 12.4 years, 18,651(4.1%) participants have developed depression. Regular laxative use was significantly associated with a higher risk of incident depression (vs. nonregular laxative use; adjusted hazard ratio [HR] = 1.78, 95% confidence interval [CI], 1.68-1.89). Genetic risk of depression did not significantly modify this association. The risk of incident depression increased with increasing types of laxatives used, with a HR of 1.89 (95%CI, 1.73-2.08) for use of single laxative type and 2.32 (95%CI, 1.82-2.96) for combined use of two or more laxative types ( for trend <0.001). The positive association between regular laxative use and incident depression was more pronounced in men (adjusted HR = 2.21, 95%CI, 1.96-2.48) versus women (adjusted HR = 1.67, 95%CI, 1.56-1.79; interaction <0.001). Compared to those who did not use laxatives regularly and did not have constipation, participants who used laxatives regularly and had constipation had the highest risk of incident depression (adjusted HR = 2.33, 95%CI, 1.94-2.80). Regular laxative use was significantly associated with a higher risk of incident depression, especially in men.
泻药使用与抑郁症风险之间的关系仍不明确。我们旨在评估定期使用泻药与新发抑郁症风险之间的前瞻性关联，并研究抑郁症的遗传风险是否会改变这种关联。纳入了英国生物银行中450,045名基线时无抑郁症且有泻药使用完整信息的参与者。研究结局为新发抑郁症，通过与初级保健记录、医院住院数据、死亡登记记录或随访时自我报告的医疗状况相链接得出。在中位随访12.4年期间，18,651名（4.1%）参与者患上了抑郁症。定期使用泻药与新发抑郁症风险显著升高相关（与不定期使用泻药相比；调整后的风险比[HR]=1.78，95%置信区间[CI]，1.68 - 1.89）。抑郁症的遗传风险并未显著改变这种关联。新发抑郁症的风险随着使用泻药类型的增加而升高，使用单一类型泻药时HR为1.89（95%CI，1.73 - 2.08），使用两种或更多种泻药联合使用时HR为2.32（95%CI，1.82 - 2.96）（趋势P<0.001）。定期使用泻药与新发抑郁症之间的正相关在男性中更为明显（调整后的HR=2.21，95%CI，1.96 - 2.48），而在女性中为（调整后的HR=1.67，95%CI，1.56 - 1.79；交互作用P<0.001）。与不定期使用泻药且无便秘的参与者相比，定期使用泻药且有便秘的参与者新发抑郁症的风险最高（调整后的HR=2.33，95%CI，1.94 - 2.80）。定期使用泻药与新发抑郁症风险显著升高相关，尤其是在男性中。
