后生元丁酸钠可减轻暴露于微塑料的幼年大鼠的高血压和肾功能障碍。
Postbiotic Sodium Butyrate Mitigates Hypertension and Kidney Dysfunction in Juvenile Rats Exposed to Microplastics.
作者信息
Tain You-Lin, Lin Ying-Jui, Hou Chih-Yao, Chang-Chien Guo-Ping, Lin Shu-Fen, Hsu Chien-Ning
机构信息
Division of Pediatric Nephrology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
College of Medicine, Chang Gung University, Taoyuan 330, Taiwan.
出版信息
Antioxidants (Basel). 2025 Feb 26;14(3):276. doi: 10.3390/antiox14030276.
BACKGROUND
Plastic production has led to widespread microplastic (MP) pollution, with children more vulnerable to MPs than adults. However, the mechanisms linking MP exposure to hypertension and kidney disease in children remain unclear. This study explored whether sodium butyrate, a short-chain fatty acid (SCFA) with antioxidant and anti-inflammatory properties, could mitigate MP-induced hypertension and kidney damage in juvenile rats.
METHODS
Male Sprague-Dawley rats (3 weeks old) were randomly assigned to four groups (n = 8/group): control, low-dose MP (1 mg/L), high-dose MP (10 mg/L), and high-dose MP with sodium butyrate (400 mg/kg/day). Rats were euthanized at 12 weeks.
RESULTS
High-dose MP exposure impaired kidney function and increased blood pressure, which were alleviated by sodium butyrate through reduced oxidative stress, modulation of gut microbiota, increased plasma butyric acid levels, and enhanced renal SCFA-sensing G protein-coupled receptor 43 expression.
CONCLUSIONS
Sodium butyrate holds potential for mitigating MP-induced hypertension by reducing oxidative stress, modulating the gut microbiota, and elevating butyric acid levels.
背景
塑料生产导致微塑料（MP）广泛污染，儿童比成人更容易受到微塑料的影响。然而，儿童接触微塑料与高血压和肾脏疾病之间的联系机制仍不清楚。本研究探讨了具有抗氧化和抗炎特性的短链脂肪酸丁酸钠是否可以减轻幼年大鼠微塑料诱导的高血压和肾脏损伤。
方法
将雄性Sprague-Dawley大鼠（3周龄）随机分为四组（每组n = 8）：对照组、低剂量微塑料组（1 mg/L）、高剂量微塑料组（10 mg/L）和高剂量微塑料加丁酸钠组（400 mg/kg/天）。大鼠在12周时安乐死。
结果
高剂量微塑料暴露损害了肾功能并升高了血压，丁酸钠通过降低氧化应激、调节肠道微生物群、提高血浆丁酸水平和增强肾脏短链脂肪酸传感G蛋白偶联受体43表达来缓解这些情况。
结论
丁酸钠具有通过降低氧化应激、调节肠道微生物群和提高丁酸水平来减轻微塑料诱导的高血压的潜力。
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