Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania.
Life Science Institute, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania.
Toxins (Basel). 2023 Sep 4;15(9):548. doi: 10.3390/toxins15090548.
In recent years, more scientific data have pointed out the close connection between intestinal microbial community, nutritional habits, lifestyle, and the appearance of various affections located at certain anatomical systems. Gut dysbiosis enhances the formation and accumulation of specific metabolites with toxic potential that induce the appearance of kidney-associated illnesses. Intestinal microbes are involved in the degradation of food, drugs, or other ingested products that lead to the formation of various metabolites that end up in renal tissue. Over the last few years, the possibilities of modulating the gut microbiota for the biosynthesis of targeted compounds with bioactive properties for reducing the risk of chronic illness development were investigated. In this regard, the present narrative review provides an overview of the scientific literature across the last decade considering the relationship between bioactive compounds, pre-, pro-, and post-biotics, uremic toxicity, and kidney-associated affections, and the possibility of alleviating the accumulation and the negative effects of uremic toxins into the renal system.
近年来，越来越多的科学数据指出肠道微生物群落、营养习惯、生活方式与位于特定解剖系统的各种疾病之间存在密切联系。肠道菌群失调会增强具有潜在毒性的特定代谢物的形成和积累，从而导致与肾脏相关的疾病的发生。肠道微生物参与食物、药物或其他摄入物的降解，导致各种代谢物的形成，最终进入肾脏组织。在过去的几年中，人们研究了调节肠道微生物群来生物合成具有生物活性的靶向化合物的可能性，这些化合物可以降低慢性疾病发展的风险。在这方面，本综述概述了过去十年的科学文献，考虑了生物活性化合物、前体、益生菌和后生元、尿毒症毒性以及与肾脏相关的疾病之间的关系，以及减轻尿毒症毒素在肾脏系统中积累和负面影响的可能性。
