School of Food Engineering, Food and Nutrition Department, University of Campinas, Monteiro Lobato 80, Zip Code: 13083-862, Campinas, São Paulo, Brazil.
Nutrition School- Federal University of Goias, 227 st, Qd 68, S/N-Setor Leste Universitário, Goiânia-GO, 74605-080, Brazil.
Nutr Res. 2020 Apr;76:106-117. doi: 10.1016/j.nutres.2019.08.007. Epub 2019 Aug 22.
This study investigated Passiflora edulis peel flour (PEPF) intake and its effect against high-fat diet-induced obesity. PEPF is a source of fiber and phenolic compounds, which can decrease oxidative stress and inflammatory cytokines, both linked to chronic inflammatory response and fat deposition in obesity. Therefore, we hypothesized that PEPF intake could decrease inflammatory cytokines and oxidative stress observed in obesity, leading to decrease of fatness and chronic inflammatory response. The aims of the study were to evaluate the lipid peroxidation, the expression of antioxidants enzymes, and inflammatory parameters in obese rats. Male Sprague-Dawley rats were divided into 3 groups (n = 8 per group) according to the diets: control (based on AIN-93G), high-fat (HF, 35% fat w/w), and HF with PEPF (HFPF), and the experiment lasted for 10 weeks. PEPF showed high dietary fiber content and bioactive compounds, such as ferulic acid, and β-carotene. PEPF intake was effective in reducing body weight gain (13.31%) and total body fat (22.58%). The lipid peroxidation in the liver and adipose tissue decreased in the HFPF group compared to HF-fed animals, whereas hepatic glutathione peroxidase and glutathione reductase activity and their expressions in the liver were higher in HFPF than HF. In addition, the PEPF intake decreased inflammatory cytokines in serum. These results suggest that PEPF intake decreases oxidative stress, possibly by the increase of antioxidant enzymes expression. Furthermore, PEPF decreases inflammatory response and protects from adiposity. Then, PEPF could act as an adjuvant to control of early parameters in obesity dysfunction.
这项研究调查了西番莲果皮粉（PEPF）的摄入及其对高脂肪饮食诱导肥胖的影响。PEPF 是纤维和酚类化合物的来源，可减少氧化应激和炎性细胞因子，这两者都与慢性炎症反应和肥胖中的脂肪沉积有关。因此，我们假设 PEPF 的摄入可以减少肥胖中观察到的炎性细胞因子和氧化应激，从而减少肥胖和慢性炎症反应。本研究的目的是评估肥胖大鼠的脂质过氧化、抗氧化酶表达和炎症参数。雄性 Sprague-Dawley 大鼠根据饮食分为 3 组（每组 8 只）：对照（基于 AIN-93G）、高脂肪（HF，35%脂肪 w/w）和高脂肪加 PEPF（HFPF），实验持续 10 周。PEPF 具有高膳食纤维含量和生物活性化合物，如阿魏酸和β-胡萝卜素。PEPF 的摄入有效降低了体重增加（13.31%）和总体脂肪（22.58%）。与 HF 喂养的动物相比，HFPF 组肝脏和脂肪组织中的脂质过氧化降低，而 HFPF 组肝组织中的谷胱甘肽过氧化物酶和谷胱甘肽还原酶活性及其表达更高。此外，PEPF 的摄入降低了血清中的炎性细胞因子。这些结果表明，PEPF 的摄入可通过增加抗氧化酶的表达来减少氧化应激。此外，PEPF 可降低炎症反应并防止肥胖。因此，PEPF 可作为控制肥胖功能障碍早期参数的辅助手段。
