Chen Zhijun, Liu Jinquan, Wang Wenyu, Qin Guoqing, Liu Siru, Zhang Weilin, Peng Changmin, Tan Yan, Dai Zhongran, Zhen Deshuai, Li Le
Department of Health Inspection and Quarantine, School of Public Health, Hengyang Medical School, University of South China, Hengyang, 421001, China.
Hunan Province Key Laboratory of Typical Environment Pollution and Health Hazards, University of South China, Hengyang, 421001, China.
Mikrochim Acta. 2025 Apr 14;192(5):295. doi: 10.1007/s00604-025-07156-3.
Uranium is the core material for the development of the nuclear industry, but its irreversible radiation damage poses a significant threat to human health. In this context, an innovative dual-mode colorimetric and electrochemical sensor was developed for the detection of uranyl ions (UO), utilizing a covalent organic framework@gold nanoclusters (AuNCs@COF) composite. The synthesis of AuNCs@COF was simple, and the incorporation of AuNCs imparted the composite with exceptional peroxidase-like catalytic activity and enhanced electrochemical properties. By regulating the adsorption and desorption of aptamers on the AuNCs@COF surface, both peroxidase-like activity and conductivity were modulated, enabling the detection of UO utilizing colorimetric and electrochemical dual signals. Under optimal conditions, the sensor revealed a broad linear detection range and a low detection limit, with ranges of 1.36 × 10-1.36 × 10 mol/L for colorimetric detection and 5.0 × 10-2.5 × 10 mol/L for electrochemical detection, achieving detection limits for these two methods of 107 pmol/L and 347 pmol/L, respectively. Unlike other single-mode sensors for UO detection, this dual-mode sensor demonstrated superior sensitivity, specificity, and repeatability. Furthermore, the results of spiked recovery experiments in real water samples highlight the promising potential of this dual-mode sensor for environmental water monitoring applications.
铀是核工业发展的核心材料，但其不可逆转的辐射损伤对人类健康构成重大威胁。在此背景下，利用共价有机框架@金纳米团簇（AuNCs@COF）复合材料开发了一种用于检测铀酰离子（UO）的创新型双模式比色和电化学传感器。AuNCs@COF的合成简单，AuNCs的掺入赋予了该复合材料出色的类过氧化物酶催化活性和增强的电化学性能。通过调节适配体在AuNCs@COF表面的吸附和解吸，类过氧化物酶活性和电导率均得到调控，从而能够利用比色和电化学双信号检测UO。在最佳条件下，该传感器显示出较宽的线性检测范围和较低的检测限，比色检测范围为1.36×10 - 1.36×10 mol/L，电化学检测范围为5.0×10 - 2.5×10 mol/L，这两种方法的检测限分别为107 pmol/L和347 pmol/L。与其他用于UO检测的单模式传感器不同，这种双模式传感器表现出卓越的灵敏度、特异性和可重复性。此外，实际水样中加标回收实验的结果突出了这种双模式传感器在环境水监测应用中的广阔前景。
