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采用光子计数探测器计算机断层扫描的儿科高音调肺部成像:一项剂量降低模型研究

Paediatric high-pitch lung imaging with photon-counting detector computed tomography: a dose reduction phantom study.

作者信息

Zellner Michael, Sartoretti Thomas, Flohr Thomas, Frauenfelder Thomas, Alkadhi Hatem, Kellenberger Christian J, Mergen Victor

机构信息

Department of Diagnostic Imaging, University Children's Hospital Zurich, Lenggstrasse 30, Zurich, 8008, Switzerland.

Diagnostic and Interventional Radiology, University Hospital Zurich, University Zurich, Zurich, Switzerland.

出版信息

Pediatr Radiol. 2025 May;55(6):1191-1201. doi: 10.1007/s00247-025-06235-0. Epub 2025 Apr 15.

Abstract

BACKGROUND

Photon-counting detector computed tomography (PCD-CT) can reduce radiation dose in paediatric lung imaging.

OBJECTIVE

The aim of this study was to determine the lowest radiation dose maintaining adequate image quality for high-pitch lung imaging using a PCD-CT in a chest phantom replicating the characteristics of a 5-year-old child.

MATERIALS AND METHODS

The phantom was imaged on a dual-source PCD-CT with five different volume CT dose indices (CTDI): 0.45 mGy, 0.30 mGy, 0.15 mGy, 0.07 mGy, and 0.01 mGy. Scans were acquired with Sn100 kV in standard and ultra-high resolution modes. Polychromatic images were reconstructed with a 1-mm slice thickness, lung kernel Bl60, without quantum iterative reconstruction and with quantum iterative reconstruction at strengths 2 and 4. Two paediatric radiologists rated reconstructions subjectively, defining adequate image quality as the visibility of small peripheral structures. Objective evaluation included global noise index and global signal-to-noise ratio index.

RESULTS

Exposure times were 0.42 s and 0.84 s for standard and ultra-high resolution modes, respectively. Subjective assessments showed no significant differences across scan modes or quantum iterative reconstruction strengths for both readers at all doses (all, P > 0.05). Scans at 0.07 mGy with quantum iterative reconstruction 4 were deemed to maintain adequate image quality at the lowest dose. Global noise index was always lower and global signal-to-noise ratio index always higher in ultra-high resolution compared with standard mode, underscoring noise reduction achieved via ultra-high resolution mode's small pixel effect.

CONCLUSIONS

PCD-CT enables high-pitch lung imaging while maintaining adequate image quality at a radiation dose as low as 0.07 mGy, with quantum iterative reconstruction 4, in a paediatric phantom representing a 5-year-old child.

摘要

背景

光子计数探测器计算机断层扫描(PCD-CT)可降低儿科肺部成像的辐射剂量。

目的

本研究的目的是确定在模拟5岁儿童特征的胸部体模中,使用PCD-CT进行高螺距肺部成像时,维持足够图像质量的最低辐射剂量。

材料与方法

使用五种不同的容积CT剂量指数(CTDI):0.45 mGy、0.30 mGy、0.15 mGy、0.07 mGy和0.01 mGy,在双源PCD-CT上对体模进行成像。扫描在Sn100 kV下以标准和超高分辨率模式进行采集。多色图像以1毫米层厚、肺内核Bl60重建,不使用量子迭代重建,以及使用强度为2和4的量子迭代重建。两名儿科放射科医生对重建图像进行主观评分,将足够的图像质量定义为小周边结构的可见性。客观评估包括全局噪声指数和全局信噪比指数。

结果

标准和超高分辨率模式的曝光时间分别为0.42秒和0.84秒。主观评估显示,在所有剂量下,两位读者在不同扫描模式或量子迭代重建强度之间均无显著差异(所有P>0.05)。在0.07 mGy剂量下使用量子迭代重建4的扫描被认为在最低剂量下维持了足够的图像质量。与标准模式相比,超高分辨率模式下的全局噪声指数始终较低,全局信噪比指数始终较高,这突出了通过超高分辨率模式的小像素效应实现的降噪效果。

结论

在代表5岁儿童的儿科体模中,PCD-CT能够在低至0.07 mGy的辐射剂量下进行高螺距肺部成像,并使用量子迭代重建4维持足够的图像质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41bd/12119663/4ba5f1ad7474/247_2025_6235_Fig1_HTML.jpg

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