Washington Erica J
Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, 27710, USA.
Department of Biochemistry, Duke University, Durham, NC, 27710, USA.
NPJ Antimicrob Resist. 2025 Apr 14;3(1):30. doi: 10.1038/s44259-025-00095-2.
Invasive fungal infections are responsible for millions of deaths worldwide each year. Therefore, focusing on innovative approaches to developing therapeutics that target fungal pathogens is critical. Here, we discuss targeting the fungal trehalose biosynthesis pathway with antifungal therapeutics, which may lead to the improvement of human health globally, especially as fungal pathogens continue to emerge due to fluctuations in the climate.
侵袭性真菌感染每年在全球导致数百万人死亡。因此，专注于开发针对真菌病原体的创新治疗方法至关重要。在此，我们讨论用抗真菌疗法靶向真菌海藻糖生物合成途径，这可能会改善全球人类健康，特别是鉴于由于气候变化真菌病原体不断出现的情况。
