Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
Curr Opin Microbiol. 2022 Oct;69:102198. doi: 10.1016/j.mib.2022.102198. Epub 2022 Aug 26.
Fungi have a profound impact on human health, leading to billions of infections and millions of deaths worldwide each year. Exacerbating the public health burden is the continued emergence of drug-resistant fungal pathogens coupled with a dearth of treatment options to combat serious infections. Despite this health threat, scientific advances in chemistry, genetics, and biochemistry methodologies have enabled novel antifungal compounds to be discovered. Here, we describe current approaches for the discovery and characterization of novel antifungals, focusing on the identification of novel chemical matter and elucidation of the cellular target of bioactive compounds, followed by a review of the most promising emerging therapies in the antifungal-development pipeline.
真菌对人类健康有深远的影响，每年导致全球数十亿的感染和数百万人死亡。不断出现的耐药真菌病原体以及缺乏治疗严重感染的方法，加剧了公共卫生负担。尽管存在这种健康威胁，但化学、遗传学和生物化学方法学的科学进步使新型抗真菌化合物得以发现。在这里，我们描述了新型抗真菌药物的发现和表征的当前方法，重点是鉴定新型化学物质和阐明生物活性化合物的细胞靶标，然后回顾抗真菌药物开发管线上最有前途的新兴疗法。
