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撒哈拉以南非洲地区医疗机构分娩和产前护理对新生儿死亡率的影响:倾向得分匹配分析

Impact of health facility delivery and antenatal care on neonatal mortality in Sub-Saharan Africa: a propensity score matching analysis.

作者信息

Bezie Meklit Melaku, Fente Bezawit Melak, Asmare Zufan Alamrie, Asnake Angwach Abrham, Asebe Hiwot Atlaye, Negussie Yohannes Mekuria, Seifu Beminate Lemma

机构信息

Department of Public Health Officer, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Department of General Midwifery, School of Midwifery, College of Medicine & Health Sciences, University of Gondar, Gondar, Ethiopia.

出版信息

BMC Pregnancy Childbirth. 2025 Apr 14;25(1):440. doi: 10.1186/s12884-025-07565-5.

Abstract

BACKGROUND

Even though global neonatal mortality has shown a remarkable reduction, it still constitutes 42% of the global under-five mortality. Nearly three-fourths of these deaths occurred in sub-Saharan Africa (SSA). Antenatal Care (ANC) and health facility delivery are the best-recommended strategies to prevent neonatal mortality. Previously published studies showed a significant association between ANC and health facility delivery with neonatal mortality. However, none of them examined the actual causal impact of health facility delivery and ANC on neonatal mortality in SSA using Propensity Score Matching (PSM) analysis. Therefore, our study examined the causal effect of ANC and health facility delivery on neonatal mortality in SSA using the Propensity Score Matched (PSM) analysis approach. This study adds new knowledge to the existing literature by evaluating the actual effect of health facility delivery and antenatal care on neonatal mortality by controlling confounding via matching. Which in turn enable decision makers in evaluating the effectiveness of these services in reducing neonatal mortality in SSA.

METHODS

We used the Demographic and Health Survey (DHS) data of 28 sub-Saharan African countries. About 351,940 live births were considered for this study. STATA version 18 statistical software was used for data management and analysis. We employed the Propensity Score Matching (PSM) analysis to examine the causal effect of ANC and health facility delivery on neonatal mortality. The logit model was fitted to estimate the propensity score. In the final PSM model, the average treatment effect of ANC and health facility delivery on neonatal mortality were reported. The quality of matching was checked to ensure the robustness of the results. We did sensitivity analysis to test hidden bias using the Mantel-Haenzel (MH) test statistic.

RESULTS

Neonatal mortality in SSA was 27.36 (95%: 26.83, 27.90) per 1000 live births. The Average Treatment Effect on the treated (ATT) in the PSM analysis demonstrated that ANC and health facility delivery decrease the risk of neonatal mortality by 1.04% and 0.22%, respectively. Similarly, the Average Treatment Effect on the Population (ATE) showed that ANC and health facility delivery reduce neonatal mortality by 1.04% and 0.22%, respectively. The quality of matching was good and the results were not sensitive to hidden bias. The treatment and control groups were well comparable for the baseline confounders after matching (p-value > 0.05).

CONCLUSION

Our study found that ANC and health facility delivery significantly contributed to the reduction of neonatal mortality after matching the treatment and control groups by observed variables. These findings highlighted that maternal and newborn health care programs and policies could enhance maternal health service utilization in SSA to reduce neonatal mortality.

摘要

背景

尽管全球新生儿死亡率已显著下降,但仍占全球五岁以下儿童死亡率的42%。其中近四分之三的死亡发生在撒哈拉以南非洲(SSA)。产前保健(ANC)和在医疗机构分娩是预防新生儿死亡的最佳推荐策略。先前发表的研究表明,ANC和在医疗机构分娩与新生儿死亡率之间存在显著关联。然而,它们均未使用倾向得分匹配(PSM)分析来检验在医疗机构分娩和ANC对SSA新生儿死亡率的实际因果影响。因此,我们的研究采用倾向得分匹配(PSM)分析方法,检验了ANC和在医疗机构分娩对SSA新生儿死亡率的因果效应。本研究通过匹配控制混杂因素,评估在医疗机构分娩和产前保健对新生儿死亡率的实际影响,为现有文献增添了新知识。这反过来使决策者能够评估这些服务在降低SSA新生儿死亡率方面的有效性。

方法

我们使用了28个撒哈拉以南非洲国家的人口与健康调查(DHS)数据。本研究纳入了约351,940例活产。使用STATA 18统计软件进行数据管理和分析。我们采用倾向得分匹配(PSM)分析来检验ANC和在医疗机构分娩对新生儿死亡率的因果效应。拟合logit模型以估计倾向得分。在最终的PSM模型中,报告了ANC和在医疗机构分娩对新生儿死亡率的平均治疗效果。检查匹配质量以确保结果的稳健性。我们使用Mantel-Haenzel(MH)检验统计量进行敏感性分析,以检验潜在偏倚。

结果

SSA的新生儿死亡率为每1000例活产27.36例(95%:26.83,27.90)。PSM分析中的处理组平均治疗效果(ATT)表明,ANC和在医疗机构分娩分别使新生儿死亡风险降低了1.04%和0.22%。同样,总体平均治疗效果(ATE)表明,ANC和在医疗机构分娩分别使新生儿死亡率降低了1.04%和0.22%。匹配质量良好,结果对潜在偏倚不敏感。匹配后,处理组和对照组在基线混杂因素方面具有良好的可比性(p值>0.05)。

结论

我们的研究发现,在通过观察变量对处理组和对照组进行匹配后,ANC和在医疗机构分娩对降低新生儿死亡率有显著贡献。这些发现突出表明,孕产妇和新生儿保健计划及政策可提高SSA孕产妇保健服务的利用率,以降低新生儿死亡率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec9c/11995656/3477aa888c41/12884_2025_7565_Fig1_HTML.jpg

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