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评估出生间隔对东非国家五岁以下儿童死亡率的影响:倾向得分匹配分析

Estimating the impact of birth interval on under-five mortality in east african countries: a propensity score matching analysis.

作者信息

Tesema Getayeneh Antehunegn, Worku Misganaw Gebrie, Alamneh Tesfa Sewunet, Teshale Achamyeleh Birhanu, Yeshaw Yigizie, Alem Adugnaw Zeleke, Ayalew Hiwotie Getaneh, Liyew Alemneh Mekuriaw, Tessema Zemenu Tadesse

机构信息

Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences and comprehensive specialized hospital, University of Gondar, Gondar, Ethiopia.

Department of human anatomy, College of Medicine and Health Sciences and comprehensive specialized hospital, University of Gondar, Gondar, Ethiopia.

出版信息

Arch Public Health. 2023 Apr 21;81(1):63. doi: 10.1186/s13690-023-01092-5.

Abstract

BACKGROUND

Under-five mortality remains a global public health concern, particularly in East African countries. Short birth interval is highly associated with under-five mortality, and birth spacing has a significant effect on a child's likelihood of survival. The association between short birth intervals and under-five mortality was demonstrated by numerous observational studies. However, the effect of short birth intervals on under-five mortality has not been investigated yet. Therefore, this study aimed to investigate the impact of short birth intervals on under-five mortality in East Africa using Propensity Matched Analysis.

METHODS

A secondary data analysis was conducted based on the most recent Demographic and Health Survey (DHS) data of 12 East African countries. A total weighted sample of 105,662 live births was considered for this study. A PSM analysis was carried out to evaluate the effect of short birth intervals on under-five mortality. Under-five mortality was the outcome variable, while the short birth interval was considered a treatment variable. To determine the Average Treatment Effect on the population (ATE), Average Treatment Effect on the treated (ATT), and Average Treatment Effect on the untreated (ATU), we performed PSM analysis with a logit-based model using the psmatch2 ate STATA function. The quality of matching was assessed statistically and graphically. The common support assumption was checked and fulfilled. We have employed Mantel-Haenszel bounds to examine whether the result would be free from hidden bias or not.

RESULTS

The prevalence of short birth intervals in East Africa was 44%. The under-five mortality rate among mothers who had optimal birth intervals was 39.9 (95% CI: 38.3, 41.5) per 1000 live births while it was 60.6 (95% CI: 58.5, 62.8) per 1000 live births among mothers who had a short birth intervals. Propensity score matching split births from mothers into treatment and control groups based on the preceding birth interval. In the PSM analysis, the ATT values in the treated and control groups were 6.09% and 3.97%, respectively, showed under-five mortality among births to mothers with short birth intervals was 2.17% higher than births to mothers who had an optimal birth interval. The ATU values in the intervention and control groups were 3.90% and 6.06%, respectively, indicating that for births from women who had an optimal birth interval, the chance of dying within five years would increase by 2.17% if they were born to mother with short birth interval. The final ATE estimate was 2.14% among the population. After matching, there was no significant difference in baseline characteristics between the treated and control groups (p-value > 0.05), which indicates the quality of matching was good.

CONCLUSIONS

We conclude that enhancing mothers to have optimal birth spacing is likely to be an effective approach to reducing the incidence of under-five mortality. Our findings suggest that births to mothers with short birth intervals have an increased risk of death in the first five years of life than births to mothers who had an optimal birth interval. Therefore, public health programs should enhance interventions targeting improving birth spacing to reduce the incidence of under-five mortality in low-and middle-income countries like East African countries. Moreover, to achieve a significant reduction in the under-five mortality rate, interventions that encourage birth spacing should be considered. This will improve child survival and help in attaining Sustainable Development Goal targets in East African countries.

摘要

背景

五岁以下儿童死亡率仍是全球公共卫生关注的问题,尤其是在东非国家。短生育间隔与五岁以下儿童死亡率高度相关,生育间隔对儿童的生存可能性有重大影响。众多观察性研究证实了短生育间隔与五岁以下儿童死亡率之间的关联。然而,短生育间隔对五岁以下儿童死亡率的影响尚未得到研究。因此,本研究旨在使用倾向匹配分析来调查东非短生育间隔对五岁以下儿童死亡率的影响。

方法

基于12个东非国家最新的人口与健康调查(DHS)数据进行二次数据分析。本研究纳入了总共105,662例活产的加权样本。进行倾向得分匹配(PSM)分析以评估短生育间隔对五岁以下儿童死亡率的影响。五岁以下儿童死亡率为结果变量,短生育间隔被视为处理变量。为了确定总体平均处理效应(ATE)、处理组平均处理效应(ATT)和未处理组平均处理效应(ATU),我们使用psmatch2 ate STATA函数,通过基于logit的模型进行PSM分析。通过统计和图形方式评估匹配质量。检查并满足了共同支持假设。我们采用Mantel-Haenszel界限来检验结果是否不存在隐藏偏差。

结果

东非短生育间隔的患病率为44%。生育间隔最佳的母亲中,五岁以下儿童死亡率为每1000例活产39.9例(95%置信区间:38.3,41.5),而生育间隔短的母亲中,这一数字为每1000例活产60.6例(95%置信区间:58.5,62.8)。倾向得分匹配根据先前的生育间隔将母亲的分娩分为处理组和对照组。在PSM分析中,处理组和对照组的ATT值分别为6.09%和3.97%,表明生育间隔短的母亲所生婴儿的五岁以下儿童死亡率比生育间隔最佳的母亲所生婴儿高2.17%。干预组和对照组的ATU值分别为3.90%和6.06%,这表明对于生育间隔最佳的母亲所生的婴儿,如果其母亲生育间隔短,则其在五岁内死亡的几率将增加2.17%。总体最终ATE估计值为2.14%。匹配后,处理组和对照组的基线特征无显著差异(p值>0.05),这表明匹配质量良好。

结论

我们得出结论,促使母亲有最佳生育间隔可能是降低五岁以下儿童死亡率的有效方法。我们的研究结果表明,生育间隔短的母亲所生婴儿在生命的头五年死亡风险高于生育间隔最佳的母亲所生婴儿。因此,公共卫生项目应加强针对改善生育间隔的干预措施,以降低东非等低收入和中等收入国家五岁以下儿童死亡率。此外,为了大幅降低五岁以下儿童死亡率,应考虑鼓励生育间隔的干预措施。这将提高儿童生存率,并有助于在东非国家实现可持续发展目标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d830/10120214/c32671d5ef5d/13690_2023_1092_Figa_HTML.jpg

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