Chen Rundong, Pang Miao, Zhang Yilei, Zhang Hongjian, Zhang Guanghao, Wei Yutian, Hua Weilong, Zhang Xiaoxi, Zhang Lei, Li Zifu, Li Qiang, Yang Pengfei
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.
Neurovascular Center, Changhai Hospital, Naval Medical University, #168 Changhai Road, Shanghai, 200433, China.
Eur J Med Res. 2025 Apr 15;30(1):283. doi: 10.1186/s40001-025-02548-w.
Atherosclerotic cardiovascular disease (ASCVD) has long been recognized as a significant contributor to mortality rates, holding a prominent position in the hierarchy of causes of death. Nevertheless, the presence of a causal relationship between serum uric acid (SUA) and the risk of ASCVD, as well as mortality rates, remains unclear.
We initially conducted a comprehensive cohort study utilizing data sourced from National Health and Nutrition Examination Survey (NHANES) 1999-2018 to investigate the specific correlation between SUA levels and ASCVD. Then, we subsequently examined the link between SUA levels and all-cause and cardio-cerebrovascular mortality among ASCVD individuals.
We identified a U-shaped relationship between SUA levels and the risk of ASCVD in all participants (inflection point at 5.399, p value = 0.014). Similarly, SUA levels showed U-shaped trends with all-cause mortality (inflection point at 5.748, p value < 0.0001) and cardio-cerebrovascular mortality (inflection point at 5.936, p value < 0.0001), respectively.
Our findings demonstrate a U-shaped association between SUA levels and the risks of ASCVD, all-cause mortality, and cardio-cerebrovascular mortality. However, further research is needed to better understand how SUA affects ASCVD and its underlying mechanisms.
动脉粥样硬化性心血管疾病（ASCVD）长期以来一直被认为是死亡率的重要促成因素，在死因层级中占据突出地位。然而，血清尿酸（SUA）与ASCVD风险以及死亡率之间是否存在因果关系仍不明确。
我们最初利用1999 - 2018年美国国家健康与营养检查调查（NHANES）的数据进行了一项全面的队列研究，以调查SUA水平与ASCVD之间的具体相关性。随后，我们研究了ASCVD患者中SUA水平与全因死亡率和心脑血管死亡率之间的联系。
我们在所有参与者中发现SUA水平与ASCVD风险之间呈U形关系（拐点为5.399，p值 = 0.014）。同样，SUA水平分别与全因死亡率（拐点为5.748，p值 < 0.0001）和心脑血管死亡率（拐点为5.936，p值 < 0.0001）呈U形趋势。
我们的研究结果表明SUA水平与ASCVD风险、全因死亡率和心脑血管死亡率之间呈U形关联。然而，需要进一步研究以更好地了解SUA如何影响ASCVD及其潜在机制。
