Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing 100005, China.
Department of Epidemiology, Capital Institute of Pediatrics, Beijing 100020, China.
Int J Environ Res Public Health. 2022 May 31;19(11):6713. doi: 10.3390/ijerph19116713.
The purpose of this cross-sectional study is to use a representative sample of the Chinese population and the atherosclerotic cardiovascular disease (ASCVD) risk assessment tool developed specifically for the Chinese to explore the prevalence of hyperuricemia (HUA) and the relationship between hyperuricemia and 10-year ASCVD risk in Chinese adults. Data was collected from the Chinese Physiological Constant and Health Condition survey. In this study, 12,988 subjects aged between 35 and 74 were selected by two-stage, cluster and random sampling. The sex-specific 10-year ASCVD risk scores equations, which were conducted by China-PAR project and specifically designed for Chinese adults, were used to assess the risk of developing ASCVD 10 years later. The ordinal regression model was used to explore the relationship between hyperuricemia and ASCVD risk. The total prevalence of hyperuricemia was 12.69%, and males' prevalence was significantly higher than females (17.7% vs. 8.5%). Compared with people without hyperuricemia, the 10-year ASCVD risk scores of female with hyperuricemia increased significantly, but no significant increased happened in male. The ordinal regression model indicated that hyperuricemia subjects were 1.3 (males, 95% CI: 1.11-1.52) and 4.34 (females, 95% CI: 3.16-5.91) times more likely to increase their ASCVD risk levels than those without hyperuricemia. In conclusion, Hyperuricemia is prevalent among Chinese adults. In both genders, hyperuricemia was related with higher risk of 10-year ASCVD, and the relationship is much stronger in females than in males. Thus, sex-specific serum uric acid management and intervention strategies should be done in the prevention and control of cardiovascular events.
本横断面研究旨在使用具有代表性的中国人群样本和专为中国人开发的动脉粥样硬化性心血管疾病（ASCVD）风险评估工具，探讨中国成年人高尿酸血症（HUA）的患病率以及高尿酸血症与 10 年 ASCVD 风险之间的关系。数据来自中国生理常数和健康状况调查。在这项研究中，通过两阶段、聚类和随机抽样方法选择了 12988 名年龄在 35 至 74 岁之间的受试者。使用由中国 PAR 项目制定的、专为中国成年人设计的特定性别 10 年 ASCVD 风险评分方程来评估 10 年后发生 ASCVD 的风险。采用有序回归模型探讨高尿酸血症与 ASCVD 风险之间的关系。高尿酸血症的总患病率为 12.69%，男性患病率明显高于女性（17.7%对 8.5%）。与无高尿酸血症者相比，女性高尿酸血症患者的 10 年 ASCVD 风险评分显著增加，但男性无显著增加。有序回归模型表明，高尿酸血症患者发生 ASCVD 的风险水平分别增加 1.3 倍（男性，95%CI：1.11-1.52）和 4.34 倍（女性，95%CI：3.16-5.91）。总之，高尿酸血症在中国成年人中较为普遍。在两性中，高尿酸血症与 ASCVD 风险增加有关，且女性的相关性强于男性。因此，应针对不同性别进行特异性血清尿酸管理和干预策略，以预防和控制心血管事件。
