Chen Xiaoling, He Xiaoling, Du Xinyi, Huang Zhiqing, Jia Gang, Zhao Hua
Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.
J Anim Sci. 2025 Jan 4;103. doi: 10.1093/jas/skaf114.
This study explored the effects of dihydromyricetin (DHM) on lipopolysaccharide (LPS)-induced intestinal injury in weaned piglets and also investigated its possible molecular mechanism. The results showed that dietary supplementation of DHM could improve the jejunum morphological structure of piglets induced by LPS, reduce jejunum mucosa inflammation and endoplasmic reticulum stress, increase jejunum mucosa antioxidant capacity and the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and improve jejunum mucosa permeability. In addition, DHM downregulated the expression of toll-like receptor 4 (TLR4), phosphor-nuclear factor kappa-B (NF-κB), hypoxia-inducible factor-1α (HIF-1α), and the activation of the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome. Taken together, LPS could induce jejunum mucosa injury in weaned piglets, but dietary supplementation of DHM alleviated LPS-induced jejunum mucosa injury to a certain extent, and the mechanism may be related to the activation of Nrf2 to inhibit the oxidative stress and negatively regulate the activation of the TLR4/HIF-1α/NLRP3 signaling axis.
本研究探讨了二氢杨梅素（DHM）对脂多糖（LPS）诱导的断奶仔猪肠道损伤的影响，并研究了其可能的分子机制。结果表明，日粮中添加DHM可改善LPS诱导的仔猪空肠形态结构，减轻空肠黏膜炎症和内质网应激，提高空肠黏膜抗氧化能力以及核因子红细胞2相关因子2（Nrf2）的表达，并改善空肠黏膜通透性。此外，DHM下调了Toll样受体4（TLR4）、磷酸化核因子κB（NF-κB）、缺氧诱导因子-1α（HIF-1α）的表达以及含NOD样受体家族pyrin结构域蛋白3（NLRP3）炎性小体的激活。综上所述，LPS可诱导断奶仔猪空肠黏膜损伤，但日粮中添加DHM可在一定程度上减轻LPS诱导的空肠黏膜损伤，其机制可能与激活Nrf2以抑制氧化应激并负向调节TLR4/HIF-1α/NLRP3信号轴的激活有关。
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