Winkler S S, Sackett J F, Holden J E, Flemming D C, Alexander S C, Madsen M, Kimmel R I
Invest Radiol. 1977 Jan-Feb;12(1):15-8. doi: 10.1097/00004424-197701000-00005.
The purpose of this study is to determine whether computerized tomography can distinguish between brain tissue and brain tissue containing dissolved xenon at physiologic concentrations. Xenon is an inert gas of high atomic number (54), and is highly soluble in tissue, particularly in fat. Its presence in the brain after inhalation is manifested by well known anesthetic effects. Phantom studies using xenon in equilibrium at atomospheric pressure with water, corn oil, and milk samples of varying known fat content, demonstrate that xenon is detectable in all cases with a steep linear increase in change of attenuation factor (EMI number) with increasing fat content. In the rhesus monkey xenon is readily detectable at 20% inhaled gas concentration, with linear detectable at 20% inhaled gas concentration, with linear increase of attenuation factor with increasing concentration. The possible application of our findings to the study of brain pathophysiology is discussed. Since xenon is a potent although safe anesthestic, caution in clinical application is advised.
本研究的目的是确定计算机断层扫描能否区分脑组织与含有生理浓度溶解氙气的脑组织。氙是一种原子序数较高（54）的惰性气体，在组织中高度可溶，尤其是在脂肪中。吸入后其在大脑中的存在表现为众所周知的麻醉作用。使用氙在大气压下与水、玉米油和已知不同脂肪含量的牛奶样本达到平衡的模型研究表明，在所有情况下都能检测到氙，随着脂肪含量增加，衰减系数（EMI值）变化呈陡峭线性增加。在恒河猴中，吸入气体浓度为20%时很容易检测到氙，随着浓度增加，衰减系数呈线性增加。讨论了我们的研究结果在脑病理生理学研究中的可能应用。由于氙是一种强效但安全的麻醉剂，建议在临床应用中谨慎使用。
