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Fluorescence optical imaging in anticancer drug delivery.抗癌药物递送中的荧光光学成像。
J Control Release. 2016 Mar 28;226:168-81. doi: 10.1016/j.jconrel.2016.02.022. Epub 2016 Feb 16.
2
Xenon Anesthesia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.氙气麻醉：随机对照试验的系统评价与荟萃分析
Anesth Analg. 2016 Mar;122(3):678-697. doi: 10.1213/ANE.0000000000000914.
3
Genetic and anatomical basis of the barrier separating wakefulness and anesthetic-induced unresponsiveness.清醒与麻醉诱导无反应之间的屏障的遗传和解剖学基础。
PLoS Genet. 2013;9(9):e1003605. doi: 10.1371/journal.pgen.1003605. Epub 2013 Sep 5.
4
Emerging trends in in vivo neurochemical monitoring by microdialysis.微透析活体神经化学监测的新趋势。
Curr Opin Chem Biol. 2013 Oct;17(5):860-7. doi: 10.1016/j.cbpa.2013.06.012. Epub 2013 Jul 12.
5
A conserved behavioral state barrier impedes transitions between anesthetic-induced unconsciousness and wakefulness: evidence for neural inertia.一种保守的行为状态障碍阻碍了麻醉诱导的无意识和觉醒之间的转变：神经惯性的证据。
PLoS One. 2010 Jul 30;5(7):e11903. doi: 10.1371/journal.pone.0011903.
6
Bispectral index, entropy, and quantitative electroencephalogram during single-agent xenon anesthesia.单剂氙气麻醉期间的脑电双频指数、熵和定量脑电图
Anesthesiology. 2008 Jan;108(1):63-70. doi: 10.1097/01.anes.0000296106.52472.a6.
7
Xenon measurement in breathing systems: a comparison of ultrasonic and thermal conductivity methods.呼吸系统中氙气的测量：超声法与热导法的比较
Anaesthesia. 2005 Dec;60(12):1226-30. doi: 10.1111/j.1365-2044.2005.04379.x.
8
Alcohol impairment of behavior in men and women.酒精对男性和女性行为的损害。
Addiction. 2004 Oct;99(10):1237-46. doi: 10.1111/j.1360-0443.2004.00805.x.
9
Xenon, a modern anaesthesia gas.氙气，一种现代麻醉气体。
Minerva Anestesiol. 2004 May;70(5):255-60.
10
Diazepam produces disinhibitory cognitive effects in male volunteers.地西泮在男性志愿者中产生去抑制性认知效应。
Psychopharmacology (Berl). 2004 Apr;173(1-2):88-97. doi: 10.1007/s00213-003-1695-4. Epub 2003 Dec 19.

氙气麻醉与CT：脑麻醉药浓度的无创测量方法

Xenon Anesthesia and CT: Noninvasive Measures of Brain Anesthetic Concentration.

作者信息

McKinstry-Wu Andrew, Carspecken Charles W, Proekt Alex, Kelz Max B

机构信息

University of Pennsylvania, Philadelphia, PA, United States.

University of Pennsylvania, Philadelphia, PA, United States.

出版信息

Methods Enzymol. 2018;602:289-298. doi: 10.1016/bs.mie.2018.01.011. Epub 2018 Mar 3.

DOI:10.1016/bs.mie.2018.01.011
PMID:29588035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6241249/
Abstract

The existence of a barrier between anesthetic behavioral state transitions has been observed across phyla, but demonstrating that such a barrier exists and is not a pharmacokinetic artifact has not yet been possible in humans. Such an investigation requires temporally precise information regarding the brain concentration of anesthetic in order to demonstrate the specific pharmacokinetic-pharmacodynamic mismatch that is hysteresis. We propose a method to noninvasively determine brain tissue anesthetic concentration using computerized tomography and the radiopaque gaseous anesthetic xenon. Such a technique can be used to investigate pharmacokinetic-pharmacodynamic mismatches in humans.

摘要

跨门观察到麻醉行为状态转换之间存在障碍，但在人类中尚未能够证明这种障碍的存在且不是药代动力学假象。这样的研究需要关于麻醉剂脑浓度的时间精确信息，以证明作为滞后现象的特定药代动力学 - 药效学不匹配。我们提出一种使用计算机断层扫描和不透射线的气态麻醉剂氙来无创确定脑组织麻醉剂浓度的方法。这种技术可用于研究人类中的药代动力学 - 药效学不匹配。