Ararame Gemechu Gelana, Senbeta Birbirsa Sefera, Chereka Alex Ayenew
Department of Pharmacy, College of Health Sciences, Mattu University, Mattu, Oromia, Ethiopia.
Departement of Health Informatics, College of Health Sciences, Mattu University, Mattu, Oromia, Ethiopia.
BMC Emerg Med. 2025 Apr 15;25(1):62. doi: 10.1186/s12873-025-01223-x.
Acute poisoning is a medical emergency that can be caused by exposure to significant levels of any chemical and has toxic consequences that typically manifest within hours of exposure, leading to significant morbidity and mortality.
This study aims to determine the pooled prevalence and determinant of poor treatment outcomes of poisoning in Ethiopia.
The searches were conducted in electronic databases such as PubMed, MEDLINE, EMBASE, Science Direct, Web of Science, and Google Scholar. Original studies were selected and published until the end of December 2024, addressing the prevalence and determinant of poor treatment outcomes (death and disability) among patients. Endnote X-8 reference manager software was used to collect and organize the search outcomes and remove duplicate articles. Important data were extracted from the included studies using a format prepared in Microsoft Excel and exported to STATA 17.0 software for outcome measure analyses. The Higgins I test statistics were used to examine heterogeneity, and a random-effects model was used to analyze the pooled prevalence and determinant of poor treatment outcomes.
Eleven research articles and 10,089 poisoned patients were included in the final analysis. This study finding showed that the pooled prevalence of poor treatment outcomes among poisoned patients was 16.13% (95% CI: 9.20, 23.05). This meta-analysis study revealed that patients living in rural areas (AOR: 2.79, 95% CI: 1.44, 5.42) and delayed time to arrival (AOR = 6.15, 95%CI: 2.46, 15.34) were determinant factors of poor treatment outcome for poisoned patients in hospitals.
This study findings stated that the pooled prevalence of poor treatment outcomes among patients was high. Patients living in rural areas and delayed time to arrival at health facilities were independent determinants of poor treatment outcomes.
急性中毒是一种医疗急症，可由接触大量任何化学物质引起，其毒性后果通常在接触数小时内显现，导致严重的发病率和死亡率。
本研究旨在确定埃塞俄比亚中毒治疗效果不佳的合并患病率及其决定因素。
在PubMed、MEDLINE、EMBASE、Science Direct、Web of Science和Google Scholar等电子数据库中进行检索。选择并发表截至2024年12月底的原始研究，这些研究涉及患者中治疗效果不佳（死亡和残疾）的患病率及其决定因素。使用Endnote X-8参考文献管理软件收集和整理检索结果，并去除重复文章。使用在Microsoft Excel中准备的格式从纳入研究中提取重要数据，并导出到STATA 17.0软件进行结果测量分析。使用Higgins I检验统计量检查异质性，并使用随机效应模型分析治疗效果不佳的合并患病率及其决定因素。
最终分析纳入了11篇研究文章和10089名中毒患者。本研究结果表明，中毒患者中治疗效果不佳的合并患病率为16.13%（95%置信区间：9.20，23.05）。这项荟萃分析研究表明，居住在农村地区的患者（优势比：2.79，95%置信区间：1.44，5.42）和延迟到达时间（优势比 = 6.15，95%置信区间：2.46，15.34）是医院中中毒患者治疗效果不佳的决定因素。
本研究结果表明，患者中治疗效果不佳的合并患病率较高。居住在农村地区的患者和延迟到达医疗机构的时间是治疗效果不佳的独立决定因素。
