Department of Internal Medicine, Institute of Health, Jimma University, Jimma, Ethiopia.
Department of Epidemiology, Wolaita Sodo University, Wolaita Sodo, Ethiopia.
BMC Neurol. 2024 Oct 14;24(1):391. doi: 10.1186/s12883-024-03894-8.
Atrial fibrillation (AF) is a significant risk factor for stroke, imposing a substantial burden on healthcare systems. While studies have shown varying AF prevalence among stroke patients, limited pooled data exists in low-resource settings like Ethiopia. This hinders our understanding of the problem's extent and limits effective prevention and management strategies. Therefore, this systematic review and meta-analysis aimed to determine the pooled prevalence of atrial fibrillation among stroke patients in Ethiopia.
The searches were carried out in electronic databases such as PubMed/MEDLINE, EMBASE, Science Direct, Web of Science, and Google Scholar. Observational study designs were selected, and studies published until 30 November 2023 addressing the prevalence of atrial fibrillation among stroke patients were identified. Endnote citation manager software version X for Windows was used to collect and organize the search outcomes and remove duplicate articles. The relevant data were extracted from the included studies using a format prepared in Microsoft Excel and exported to STATA 18.0 software for the outcome measures analyses and subgrouping.
Twenty-three research articles were included in the final analysis. These studies evaluated a total of 4,544 stroke patients, of whom 529 were diagnosed with atrial fibrillation (AF). The overall pooled prevalence of AF among stroke patients was 13% [95% CI: (10%, 17%)]. Subgroup analysis by region revealed that the highest pooled prevalence of AF was 16% [95% CI: (8%, 25%)] in the Amhara region, followed by the Oromia region at 15% [95% CI: (7%, 23%)]. In Addis Ababa City, the pooled prevalence of AF among stroke patients was 11% [95% CI: (7%, 15%)]. The Tigray region reported a pooled prevalence of 9% [95% CI: (6%, 11%)]. However, one study from the Southern Nations, Nationalities, and Peoples' Region reported a lower prevalence of AF among stroke patients at 7% [95% CI: (3%, 11%)].
In summary, the study revealed that AF is prevalent among stroke patients in Ethiopia, with regional differences in prevalence. The high prevalence of AF emphasizes the necessity for effective management strategies to prevent recurrent strokes.
PROSPERO CRD: CRD42024581661.
心房颤动（AF）是中风的一个重要危险因素，给医疗系统带来了巨大负担。尽管研究表明中风患者中的 AF 患病率存在差异，但在埃塞俄比亚等资源有限的国家，汇总数据有限。这阻碍了我们对问题严重程度的理解，并限制了有效的预防和管理策略。因此，本系统评价和荟萃分析旨在确定埃塞俄比亚中风患者中心房颤动的汇总患病率。
在 PubMed/MEDLINE、EMBASE、Science Direct、Web of Science 和 Google Scholar 等电子数据库中进行了检索。选择观察性研究设计，并确定了截至 2023 年 11 月 30 日发表的关于中风患者中心房颤动患病率的研究。Endnote 引文管理器软件版本 X for Windows 用于收集和组织搜索结果并删除重复文章。使用 Microsoft Excel 中准备的格式从纳入的研究中提取相关数据，并将其导出到 STATA 18.0 软件进行结局测量分析和亚组分析。
最终分析纳入了 23 篇研究文章。这些研究共评估了 4544 名中风患者，其中 529 名被诊断为心房颤动（AF）。中风患者中 AF 的总体汇总患病率为 13%[95%CI：（10%，17%）]。按地区进行的亚组分析显示，在阿姆哈拉地区 AF 的最高汇总患病率为 16%[95%CI：（8%，25%）]，其次是奥罗米亚地区为 15%[95%CI：（7%，23%）]。在亚的斯亚贝巴市，中风患者中 AF 的汇总患病率为 11%[95%CI：（7%，15%）]。提格雷地区报告的中风患者中 AF 的汇总患病率为 9%[95%CI：（6%，11%）]。然而，来自南部民族、国家和人民地区的一项研究报告称，中风患者中 AF 的患病率较低，为 7%[95%CI：（3%，11%）]。
总之，该研究表明 AF 在埃塞俄比亚中风患者中较为普遍，且存在地区间的患病率差异。AF 的高患病率强调了制定有效的管理策略以预防中风复发的必要性。
PROSPERO CRD：CRD42024581661。
