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生物性改善病情抗风湿药物的感染风险

Infection Risk in Biological Disease-Modifying Anti-rheumatic Drugs.

作者信息

Isa Mourushi, Ramos Ma Rosario Rufina, Kamal Shahed

机构信息

General Medicine, Northern Health, Melbourne, AUS.

Medicine, Ateneo School of Medicine and Public Health, Pasig, PHL.

出版信息

Cureus. 2025 Mar 15;17(3):e80634. doi: 10.7759/cureus.80634. eCollection 2025 Mar.

DOI:10.7759/cureus.80634
PMID:40236366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11998624/
Abstract

Rheumatology patients on biological disease-modifying anti-rheumatic drugs (bDMARDs) have been proposed to be at a higher risk of infections. Our review summarizes the current evidence behind this theory as well as explores which factors predispose patients to various infections, which agents are more likely to cause infections, and which infections are common in these patients. We also aim to explore updated guidelines on infection prevention in patients on bDMARDs.

摘要

有观点认为,使用生物性改善病情抗风湿药(bDMARDs)的风湿病患者感染风险更高。我们的综述总结了这一理论背后的现有证据,并探讨了哪些因素使患者易发生各种感染、哪些药物更易导致感染以及这些患者中常见哪些感染。我们还旨在探索bDMARDs治疗患者感染预防的最新指南。

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本文引用的文献

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The regulatory T cell-selective interleukin-2 receptor agonist rezpegaldesleukin in the treatment of inflammatory skin diseases: two randomized, double-blind, placebo-controlled phase 1b trials.调控性 T 细胞选择性白介素-2 受体激动剂 rezpegaldesleukin 治疗炎症性皮肤病:两项随机、双盲、安慰剂对照的 1b 期试验。
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Risk for latent tuberculosis infection reactivation among patients with psoriasis on biologics treatment: A meta-analysis.接受生物制剂治疗的银屑病患者发生潜伏性结核感染再激活的风险:一项荟萃分析。
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Risk of infections in psoriatic arthritis or axial spondyloarthritis patients treated with targeted therapies: A meta-analysis of randomized controlled trials.靶向治疗治疗的银屑病关节炎或中轴型脊柱关节炎患者的感染风险:一项随机对照试验的荟萃分析。
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Cancer Risk in Patients Treated with the JAK Inhibitor Tofacitinib: Systematic Review and Meta-Analysis.接受JAK抑制剂托法替布治疗患者的癌症风险:系统评价与荟萃分析
Cancers (Basel). 2023 Apr 7;15(8):2197. doi: 10.3390/cancers15082197.
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Cancer risks with JAKi and biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis or psoriatic arthritis: a national real-world cohort study.类风湿关节炎或银屑病关节炎患者使用 JAKi 和生物性疾病修饰抗风湿药物的癌症风险:一项全国真实世界队列研究。
Ann Rheum Dis. 2023 Jul;82(7):911-919. doi: 10.1136/ard-2022-223636. Epub 2023 Mar 3.
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EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update.EULAR 推荐的类风湿关节炎治疗方案:使用合成和生物疾病修正抗风湿药物:2022 更新版。
Ann Rheum Dis. 2023 Jan;82(1):3-18. doi: 10.1136/ard-2022-223356. Epub 2022 Nov 10.
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Ann Rheum Dis. 2022 Jan;81(1):41-47. doi: 10.1136/annrheumdis-2021-220651. Epub 2021 Jul 28.