Dalmas Paul, Kaphan Elsa, Mortier Coline, Froidefond Margaux, Doudier Barbara, Ninove Laeticia, Nougairede Antoine, Durand Guillaume André, Lagier Jean-Christophe, Cassir Nadim
IHU Méditerranée Infection, AP-HM, Marseille, France.
Division of Internal Medicine and Clinical Immunology, Hôpital Conception, APHM, Marseille, France.
IDCases. 2025 Mar 31;40:e02213. doi: 10.1016/j.idcr.2025.e02213. eCollection 2025.
Tick-borne encephalitis virus (TBEV) is a common cause of viral encephalitis in parts of Central and Eastern Europe, with a recent resurgence of cases and geographical expansion. Active immunization results in a high rate of seroconversion and is the most effective measure to reduce the incidence of tick-borne encephalitis (TBE). In France, an endemic country, vaccination is recommended only for travelers staying in rural or forested areas in endemic regions. Polyvalent intravenous immunoglobulin (IVIG) is sometimes used as rescue treatment of viral encephalitis. However, few cases of TBEV meningoencephalitis treated with polyvalent IVIG have been described. We report here a case of autochthonous TBEV meningoencephalitis in a French patient with cranial nerve involvement that was treated with IVIG and discuss the possible mechanisms of action.
蜱传脑炎病毒（TBEV）是中欧和东欧部分地区病毒性脑炎的常见病因，近期病例有所回升且地域范围不断扩大。主动免疫可导致高血清转化率，是降低蜱传脑炎（TBE）发病率的最有效措施。在法国这个地方病流行国家，仅建议前往流行地区农村或林区的旅行者接种疫苗。多价静脉注射免疫球蛋白（IVIG）有时用作病毒性脑炎的抢救治疗。然而，很少有使用多价IVIG治疗TBEV脑膜脑炎的病例报道。我们在此报告一例法国患者的本土TBEV脑膜脑炎病例，该患者伴有颅神经受累，接受了IVIG治疗，并讨论了可能的作用机制。
