阿朴吗啡抑制催乳素分泌，但不抑制促甲状腺激素对促甲状腺激素释放激素的反应。

Apomorpine inhibits the prolactin but not the TSH response to thyrotropin releasing hormone.

作者信息

Cooper D S, Jacobs L S

出版信息

J Clin Endocrinol Metab. 1977 Feb;44(2):404-7. doi: 10.1210/jcem-44-2-404.

Abstract

Pretreatment of normal subjects with apomorphine, a dopamine receptor agonist, resulted in significant impairment of the subsequent prolactin (PRL) response to thyrotropin releasing hormone (TRH). The mean maximal increment of PRL was 27.9+/-2.4 ng/ml after TRH alone, and 11.9+/-3.0 ng/ml (P less than 0.001) after apomorphine plus TRH. In contrast, the.thyrotropin (TSH) response to TRH was unaffected by apomorphine (10.5+/-2.9 vs. 9.5+/-1.8 muU/ml, P greater than 0.5). These results demonstrate that dopaminergic effects are capable of inhibiting PRL responses to TRH, probably via a direct effect on the lactotrope cell. They also suggest that dopaminergic influences are not important in the regulation of TSH secretion.

摘要

用多巴胺受体激动剂阿扑吗啡对正常受试者进行预处理，会导致随后催乳素（PRL）对促甲状腺激素释放激素（TRH）的反应显著受损。单独给予TRH后，PRL的平均最大增加值为27.9±2.4 ng/ml，而在阿扑吗啡加TRH后为11.9±3.0 ng/ml（P<0.001）。相比之下，阿扑吗啡对TRH促甲状腺激素（TSH）的反应没有影响（分别为10.5±2.9与9.5±1.8 μU/ml，P>0.5）。这些结果表明，多巴胺能效应能够抑制PRL对TRH的反应，可能是通过对催乳素细胞的直接作用。它们还表明，多巴胺能影响在TSH分泌调节中并不重要。