Konan Yao Jean Rodrigue, Ta Bi Tra Dieudonné, Berté Djakaridja, Coulibaly Bamoro, Coulibaly Kinifo Donatien, Egnankon Nick Steven, Diarrassouba Foungniguée, Djabo Kouassi Albert, Watier-Grillot Stéphanie, Demoncheaux Jean-Paul, De Marie Kouadio Koffi Alain, N'Dri Louis, Solano Philippe, Ravel Sophie, Adingra Guy Pacôme, Barreaux Antoine, Ségard Adeline, Kaba Dramane, Jamonneau Vincent, De Meeûs Thierry, Djohan Vincent
Institut Pierre Richet, Institut National de Sante Publique, 01 BP 1500, Bouaké, Côte d'Ivoire - Université Felix Houphouët-Boigny, 01 BPV 34, Abidjan, Côte d'Ivoire.
Institut Pierre Richet, Institut National de Sante Publique, 01 BP 1500, Bouaké, Côte d'Ivoire.
Parasite. 2025;32:25. doi: 10.1051/parasite/2025017. Epub 2025 Apr 15.
Vector control (VC) is one of the strategies employed to manage African trypanosomoses. This study aimed at assessing the effectiveness of a VC campaign against Glossina palpalis palpalis using tiny targets (TTs) impregnated with insecticide in an isolated, protected forest in Abidjan, Côte d'Ivoire, while considering ecological, genetic, and operational factors. Between January 2020 and September 2022, 2,712 TTs were deployed at 684 sites, covering a total area of 1.7 km. VC monitoring was conducted using Vavoua traps during 12 evaluation surveys, between June 2020 and March 2023. Five months after the initial TT deployment, tsetse fly density had decreased by 98.53%. Although tsetse density remained low due to TT redeployment and reinforcement, there was a significant increase a few months after the last redeployment. VC appeared to have minimal impact on the genetic structuring of G. p. palpalis. This suggested recruitment of local surviving tsetse flies all along the VC campaign due to a low probability of tsetse coming into contact with TTs, or to the evolution of behavioral or physiological resistance to control efforts. The genetic study revealed that one of the microsatellite markers used, the GPCAG locus, exhibited a selection signature possibly in response to VC. This could partly explain the challenges encountered in eliminating a seemingly isolated tsetse population thriving in a particularly favorable habitat.
病媒控制（VC）是用于管理非洲锥虫病的策略之一。本研究旨在评估在科特迪瓦阿比让一个与世隔绝的保护森林中，使用浸渍杀虫剂的微小目标（TTs）开展的病媒控制活动对冈比亚按蚊指名亚种的有效性，同时考虑生态、遗传和操作因素。在2020年1月至2022年9月期间，在684个地点部署了2712个微小目标，覆盖总面积1.7平方公里。在2020年6月至2023年3月期间的12次评估调查中，使用瓦武阿诱捕器进行病媒控制监测。在首次部署微小目标五个月后，采采蝇密度下降了98.53%。尽管由于重新部署和加强微小目标，采采蝇密度仍然较低，但在最后一次重新部署几个月后出现了显著增加。病媒控制似乎对冈比亚按蚊指名亚种的遗传结构影响最小。这表明在整个病媒控制活动中，由于采采蝇接触微小目标的概率较低，或者对控制措施产生行为或生理抗性的进化，当地存活的采采蝇被招募。遗传研究表明，所使用的微卫星标记之一GPCAG位点表现出可能对病媒控制有反应的选择特征。这可以部分解释在消灭一个在特别有利栖息地中繁衍生息的看似孤立的采采蝇种群时遇到的挑战。
