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本文引用的文献

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Knowledge, attitudes, and practices regarding antibiotic use and resistance among health science and non-health science university students in Thailand.泰国卫生科学和非卫生科学专业大学生对抗生素使用和耐药性的知识、态度和实践。
PLoS One. 2024 Jan 5;19(1):e0296822. doi: 10.1371/journal.pone.0296822. eCollection 2024.
2
Impact of the COVID-19 pandemic on the Thai population: Delineating the effects of the pandemic and policy measures.新冠疫情对泰国人口的影响:描绘疫情及政策措施的影响
Antimicrob Steward Healthc Epidemiol. 2023 Dec 18;3(1):e241. doi: 10.1017/ash.2023.523. eCollection 2023.
3
Prevalence and related factors of non-adherence to antibiotics among the general public: a cross-sectional study in China.公众对抗生素不依从的流行率及其相关因素:一项在中国开展的横断面研究。
Expert Rev Anti Infect Ther. 2023 Jul-Dec;21(12):1383-1388. doi: 10.1080/14787210.2023.2268280. Epub 2023 Nov 24.
4
Changes in antibiotic prescribing by dentists in the United States, 2012-2019.美国牙医抗生素处方的变化,2012-2019 年。
Infect Control Hosp Epidemiol. 2023 Nov;44(11):1725-1730. doi: 10.1017/ice.2023.151. Epub 2023 Aug 22.
5
Economic burden of antimicrobial resistance and inappropriate empiric treatment in Thailand.泰国抗菌药物耐药性及不恰当经验性治疗的经济负担
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6
Antibiotics Use in COVID-19 Patients: A Systematic Literature Review.COVID-19患者的抗生素使用:一项系统文献综述
J Clin Med. 2022 Dec 4;11(23):7207. doi: 10.3390/jcm11237207.
7
Population knowledge and awareness of antibiotic use and antimicrobial resistance: results from national household survey 2019 and changes from 2017.人口对抗生素使用和抗微生物药物耐药性的知识和认识:来自 2019 年全国家庭调查的结果以及与 2017 年相比的变化。
BMC Public Health. 2021 Nov 29;21(1):2188. doi: 10.1186/s12889-021-12237-y.
8
Antibiotic Prescribing Habits and Antimicrobial Resistance Awareness of Dental Practitioners in Primorsko-Goranska County, Croatia.克罗地亚普里莫斯卡-戈里纳县牙医的抗生素处方习惯和抗菌药物耐药性认知。
Microb Drug Resist. 2021 Nov;27(11):1482-1488. doi: 10.1089/mdr.2020.0478. Epub 2021 Apr 28.
9
Antimicrobial Resistance Threats in the emerging COVID-19 pandemic: Where do we stand?新冠疫情期间出现的抗菌药物耐药性威胁:我们处于何种境地?
J Infect Public Health. 2021 May;14(5):555-560. doi: 10.1016/j.jiph.2021.02.011. Epub 2021 Mar 5.
10
Antibiotics' Use in Thailand: Community Pharmacists' Knowledge, Attitudes and Practices.抗生素在泰国的使用:社区药剂师的知识、态度与实践
Antibiotics (Basel). 2021 Jan 31;10(2):137. doi: 10.3390/antibiotics10020137.

新冠疫情后泰国抗生素使用模式的相关因素

Factors associated with antibiotic use patterns in Thailand after COVID-19.

作者信息

Yanarueng Supachai, Prasit Nakarin, Phimha Surachai, Nonthamat Ampawan, Nilnate Nathakon, Nidthumsakul Nattaporn, Sresutham Puwanart

机构信息

Sirindhorn College of Public Health Ubon Ratchathani, Ubon Ratchathani, Thailand.

Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand.

出版信息

Sci Rep. 2025 Apr 16;15(1):13202. doi: 10.1038/s41598-025-97936-x.

DOI:10.1038/s41598-025-97936-x
PMID:40240458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12003889/
Abstract

The misuse of antibiotics has become a significant problem in Thailand and was particularly exacerbated after the COVID-19 pandemic. Increased access to antibiotics during the pandemic has led to a heightened risk of irrational antibiotic use. This study aimed to analyze the relationships and identify factors associated with antibiotic usage behavior among the Thai population. To examine the factors influencing antibiotic use behavior in Thailand post-COVID-19 and to provide recommendations for targeted interventions. This study utilized secondary data from the 2021 health and welfare survey conducted by the National Statistical Office of Thailand. A total sample of 25,833 individuals was analyzed using multiple logistic regression, adjusting for covariates including demographic factors, health status, and healthcare utilization patterns. The key factors influencing antibiotic use included experiencing illness (adjusted OR: 6.74, 95% CI: 6.11-7.44), sustaining injuries from accidents (adjusted OR: 2.84, 95% CI: 2.19-3.67), receiving dental care (adjusted OR: 1.44, 95% CI: 1.25-1.66), and illness without hospital admission (adjusted OR: 1.60, 95% CI: 1.23-2.10). Additionally, knowledge of antibiotic use was significantly associated with antibiotic use behavior, with those having low knowledge showing higher odds of antibiotic use compared to those with high knowledge (adjusted OR: 2.75, 95% CI: 2.32-3.27). The findings highlight the need for targeted interventions to address inappropriate antibiotic use. The government and relevant agencies should promote health awareness and literacy, develop effective medication, and implement stricter regulations to minimize the adverse effects of antibiotic misuse. Enhanced public education and ensuring access to accurate information from healthcare professionals are essential for mitigating the threat of antimicrobial resistance in Thailand.

摘要

抗生素的滥用已成为泰国的一个重大问题,在新冠疫情之后尤其加剧。疫情期间抗生素获取渠道增多,导致不合理使用抗生素的风险增加。本研究旨在分析泰国人群中抗生素使用行为之间的关系,并确定与之相关的因素。以研究新冠疫情后影响泰国抗生素使用行为的因素,并为有针对性的干预措施提供建议。本研究利用了泰国国家统计局2021年健康与福利调查的二手数据。使用多元逻辑回归分析了总共25833名个体的样本,并对包括人口因素、健康状况和医疗利用模式在内的协变量进行了调整。影响抗生素使用的关键因素包括患病(调整后的比值比:6.74,95%置信区间:6.11 - 7.44)、因事故受伤(调整后的比值比:2.84,95%置信区间:2.19 - 3.67)、接受牙科护理(调整后的比值比:1.44,95%置信区间:1.25 - 1.66)以及患病但未住院(调整后的比值比:1.60,95%置信区间:1.23 - 2.10)。此外,抗生素使用知识与抗生素使用行为显著相关,与知识水平高的人相比,知识水平低的人使用抗生素的几率更高(调整后的比值比:2.75,95%置信区间:2.32 - 3.27)。研究结果凸显了采取针对性干预措施以解决不适当抗生素使用问题的必要性。政府和相关机构应提高健康意识和素养,开发有效的药物,并实施更严格的法规,以尽量减少抗生素滥用的不良影响。加强公众教育并确保从医疗专业人员处获取准确信息对于减轻泰国抗菌药物耐药性的威胁至关重要。