Verdicchio Mario, Grassi Francesco, Esposito Giuseppina, Cavaliere Carlo, Alfano Vincenzo, Cerrone Marco, Pappatà Sabina, Salvatore Elena, Di Cecca Angelica, Salvatore Marco, Aiello Marco
IRCCS SYNLAB SDN, 80142, Naples, Italy.
DIETI, Università degli Studi di Napoli Federico II, 80133, Naples, Italy.
Sci Rep. 2025 Apr 16;15(1):13111. doi: 10.1038/s41598-025-87224-z.
Estimating the volume of brain structures and white matter lesions has been demonstrated to be crucial as diagnostic markers of dementia. In this context, employing accelerated MR sequences could be particularly suitable for deploying comfortable imaging protocols. The aims of the study are twofold. First, the quality of accelerated structural and FLAIR sequences will be evaluated using conventional sequences as a comparative reference. Second, their concordance in the estimation of diagnostic markers will be assessed. Forty-six dementia patients underwent brain 3T MR protocol, including conventional and accelerated 3D T1w and 3D FLAIR sequences. The image quality was assessed using peak signal-to-noise ratio, structural similarity index measure, and mean squared error. The intraclass correlation and the Dice similarity coefficients were used to compare the markers. The quality assessment showed high agreement between accelerated and conventional sequences. Excellent concordance was demonstrated in the quantification of brain structures and white matter lesions. The results demonstrate the reliability of diagnostic markers of dementia derived from accelerated MR sequences, thereby supporting their use in clinical practice.
估计脑结构和白质病变的体积已被证明是痴呆症诊断标志物的关键。在这种情况下，采用加速磁共振序列可能特别适合部署舒适的成像方案。该研究有两个目的。首先，将使用传统序列作为比较参考来评估加速结构序列和液体衰减反转恢复（FLAIR）序列的质量。其次，将评估它们在诊断标志物估计中的一致性。46名痴呆症患者接受了脑部3T磁共振成像检查，包括传统的和加速的三维T1加权成像（3D T1w）及三维FLAIR序列。使用峰值信噪比、结构相似性指数测量和均方误差来评估图像质量。使用组内相关系数和骰子相似性系数来比较标志物。质量评估显示加速序列和传统序列之间高度一致。在脑结构和白质病变的量化方面表现出极好的一致性。结果证明了源自加速磁共振序列的痴呆症诊断标志物的可靠性，从而支持它们在临床实践中的应用。
