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Do infections have a role in Alzheimer's disease?

作者信息

Eisenstein Michael

出版信息

Nature. 2025 Apr;640(8059):S8-S10. doi: 10.1038/d41586-025-01104-0.

DOI:10.1038/d41586-025-01104-0
PMID:40240846
Abstract
摘要

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Do infections have a role in Alzheimer's disease?感染在阿尔茨海默病中起作用吗?
Nature. 2025 Apr;640(8059):S8-S10. doi: 10.1038/d41586-025-01104-0.
2
Molecular properties underlying regional vulnerability to Alzheimer's disease pathology.导致阿尔茨海默病病理区域性易损性的分子特性。
Brain. 2018 Sep 1;141(9):2755-2771. doi: 10.1093/brain/awy189.
3
Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease.正常、轻度认知障碍和阿尔茨海默病患者的连续淀粉样蛋白成像和磁共振成像:对阿尔茨海默病病理事件顺序的启示
Brain. 2009 May;132(Pt 5):1355-65. doi: 10.1093/brain/awp062. Epub 2009 Mar 31.
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Neuroscience learning from longitudinal cohort studies of Alzheimer's disease: Lessons for disease-modifying drug programs and an introduction to the Center for Neurodegeneration and Translational Neuroscience.从阿尔茨海默病纵向队列研究中学习神经科学:对疾病修饰药物项目的启示以及神经退行性变与转化神经科学中心简介
Alzheimers Dement (N Y). 2018 Jul 11;4:350-356. doi: 10.1016/j.trci.2018.06.006. eCollection 2018.
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Alzheimer's Related Neurodegeneration Mediates Air Pollution Effects on Medial Temporal Lobe Atrophy.阿尔茨海默病相关神经退行性变介导空气污染对内侧颞叶萎缩的影响。
medRxiv. 2023 Nov 29:2023.11.29.23299144. doi: 10.1101/2023.11.29.23299144.
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Brain Ischemia as a Prelude to Alzheimer's Disease.脑缺血——阿尔茨海默病的前奏
Front Aging Neurosci. 2021 Feb 18;13:636653. doi: 10.3389/fnagi.2021.636653. eCollection 2021.
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A microglia clonal inflammatory disorder in Alzheimer's disease.阿尔茨海默病中的一种小胶质细胞克隆性炎症性疾病。
Elife. 2025 Mar 14;13:RP96519. doi: 10.7554/eLife.96519.
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EEG evidence of compensatory mechanisms in preclinical Alzheimer's disease.临床前阿尔茨海默病中补偿机制的脑电图证据。
Brain. 2019 Jul 1;142(7):2096-2112. doi: 10.1093/brain/awz150.
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The potential of blood neurofilament light as a marker of neurodegeneration for Alzheimer's disease.血液神经丝轻链作为阿尔茨海默病神经退行性变标志物的潜力。
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Application of optogenetic Amyloid-β distinguishes between metabolic and physical damages in neurodegeneration.光遗传学淀粉样蛋白-β在神经退行性变中区分代谢和物理损伤的应用。
Elife. 2020 Mar 31;9:e52589. doi: 10.7554/eLife.52589.

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Physics of Protein Aggregation in Normal and Accelerated Brain Aging.正常与加速脑老化过程中蛋白质聚集的物理学
Bioessays. 2025 Aug;47(8):e70030. doi: 10.1002/bies.70030. Epub 2025 Jun 20.

本文引用的文献

1
Repetitive injury induces phenotypes associated with Alzheimer's disease by reactivating HSV-1 in a human brain tissue model.在人脑组织模型中,重复性损伤通过重新激活单纯疱疹病毒1型(HSV-1)诱导出与阿尔茨海默病相关的表型。
Sci Signal. 2025 Jan 7;18(868):eado6430. doi: 10.1126/scisignal.ado6430.
2
Establishment of a consensus protocol to explore the brain pathobiome in patients with mild cognitive impairment and Alzheimer's disease: Research outline and call for collaboration.建立共识协议以探索轻度认知障碍和阿尔茨海默病患者的脑病理生物学:研究大纲和合作呼吁。
Alzheimers Dement. 2023 Nov;19(11):5209-5231. doi: 10.1002/alz.13076. Epub 2023 Jun 7.
3
Virus exposure and neurodegenerative disease risk across national biobanks.
病毒暴露与国家生物库中的神经退行性疾病风险。
Neuron. 2023 Apr 5;111(7):1086-1093.e2. doi: 10.1016/j.neuron.2022.12.029. Epub 2023 Jan 19.
4
Signatures for viral infection and inflammation in the proximal olfactory system in familial Alzheimer's disease.家族性阿尔茨海默病患者近端嗅觉系统中病毒感染和炎症的特征。
Neurobiol Aging. 2023 Mar;123:75-82. doi: 10.1016/j.neurobiolaging.2022.12.004. Epub 2022 Dec 13.
5
Herpes simplex virus and rates of cognitive decline or whole brain atrophy in the Dominantly Inherited Alzheimer Network.单纯疱疹病毒与显性遗传性阿尔茨海默病网络中认知能力下降或全脑萎缩的发生率。
Ann Clin Transl Neurol. 2022 Nov;9(11):1727-1738. doi: 10.1002/acn3.51669. Epub 2022 Oct 3.
6
Potential Involvement of Varicella Zoster Virus in Alzheimer's Disease via Reactivation of Quiescent Herpes Simplex Virus Type 1.水痘带状疱疹病毒通过潜伏的单纯疱疹病毒 1 再激活而可能参与阿尔茨海默病。
J Alzheimers Dis. 2022;88(3):1189-1200. doi: 10.3233/JAD-220287.
7
Assessment of common infections and incident dementia using UK primary and secondary care data: a historical cohort study.利用英国初级和二级医疗保健数据评估常见感染和新发痴呆:一项历史队列研究。
Lancet Healthy Longev. 2021 Jul;2(7):e426-e435. doi: 10.1016/S2666-7568(21)00118-5.
8
Human herpesvirus infections and dementia or mild cognitive impairment: a systematic review and meta-analysis.人类疱疹病毒感染与痴呆或轻度认知障碍:系统评价和荟萃分析。
Sci Rep. 2019 Mar 18;9(1):4743. doi: 10.1038/s41598-019-41218-w.
9
in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors.在阿尔茨海默病患者大脑中:用小分子抑制剂治疗疾病的因果证据。
Sci Adv. 2019 Jan 23;5(1):eaau3333. doi: 10.1126/sciadv.aau3333. eCollection 2019 Jan.
10
Alzheimer's Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection.阿尔茨海默病相关β-淀粉样蛋白被疱疹病毒家族快速引发以抵御脑部感染。
Neuron. 2018 Jul 11;99(1):56-63.e3. doi: 10.1016/j.neuron.2018.06.030.