Sato E, Goto M, Saku T
Tohoku J Exp Med. 1985 May;146(1):9-16. doi: 10.1620/tjem.146.9.
The incidence and types of unusual nuclear structures (UNS) were examined based on the observation of randomly photographed 1,919 nuclei in total from the normal epithelium, dysplasia, Peutz-Jeghers type polyp, adenoma and carcinoma of the large bowel. These nuclear structures were classified as filamentous, granular and vesicular inclusions, and invaginated structures were also taken into consideration. Although all types of UNS were found in the normal epithelium, carcinoma cells had the most numerous UNS, especially of the invaginated type. The possible process of nuclear inclusion (NI) formation was discussed in connection with malignant transformation of colo-rectal epithelial cells.
基于对正常上皮组织、发育异常组织、黑斑息肉病型息肉、腺瘤和大肠癌中总共1919个随机拍摄细胞核的观察，对异常核结构（UNS）的发生率和类型进行了研究。这些核结构被分类为丝状、颗粒状和囊泡状包涵体，同时也考虑了内陷结构。虽然在正常上皮组织中发现了所有类型的UNS，但癌细胞中的UNS数量最多，尤其是内陷型。结合结直肠上皮细胞的恶性转化，讨论了核包涵体（NI）形成的可能过程。
